AMPL is currently funded to perform the following projects:
R01 DK121724; Funding Source: National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK); clinicaltrials.gov NCT04734847; Dates: 08/2020-04/2025, Title: Motor cortical neuromodulation in women with Interstitial Cystitis/Bladder Pain Syndrome: reducing pain by improving brain and muscle activity; Principal Investigators: Jason J. Kutch, PhD and Larissa V. Rodriguez, MD; Funding: Total Direct Costs: $1,100,000 (Total Costs: $1,815,000); Overall Aims: In this project, we will use a randomized controlled trial to test the hypothesis that repetitive transcranial magnetic stimulation (rTMS) directed at a cortical site that controls pelvic floor muscles can reduce pain, and improve brain and muscle activity in women with IC/BPS.- U01 DK082370; Funding Source: National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK); Dates:08/2019-06/2023 (NCE); Title: Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Discovery Site; Principal Investigators: Emeran Mayer, Larissa Rodriguez, and Jason J. Kutch; Funding: (USC sub-award only) Total Direct Costs: $515,040 (Total Costs: $758,927); Overall Aims: In this application the MAPP Research Network investigators propose a 3-year extension of MAPP Phase II. This will provide an additional 12 months of follow-up for the MAPP Symptom Patterns Study (SPS). It will also provide time for the MAPP investigators to analyze the large amount of MAPP Phase II data that has been collected.
We are also sub-contracted to perform 7T scanning for the following project:
- U54 DK123755 ; Funding Source: National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK); Dates: 05/30/2020 – 04/30/2025; Title: “Sex related differences in Brain Gut Microbiome Interactions in Irritable Bowel Syndrome” FY2020 Total Cost $1,584,406. Overall Aims: This SCORE proposals aims to gain a better understanding of the role of the gut microbiome and female sex hormones in the modulation of brain gut microbiome interactions in two of the most common disorders of the gastrointestinal tract, irritable bowel syndrome and chronic functional constipation. To achieve this goal it will study these interactions in 1) female patients during low estrogen states (perimenstrually, post menopausal); 2) by comparing these interactions between female and male patients and healthy control subjects and 3) by studying gut microbial and brain mechanisms underlying the effectiveness of cognitive behavioral therapy. Results obtained from the proposed studies are likely to lead to significant improvements in the treatment of these disorders.
We were recently funded for the following projects:
- R01 DK110669; Funding Source: National Institute of Diabetes and Digestive and Kidney Diseases (NIH/NIDDK); Dates: 02/2017-01/2021 (No Cost Extension through 01/2022), Title: Sensorimotor impairments in men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome: relationship of resting state brain activity to pelvic floor muscle activation; Principal Investigator: Jason J. Kutch, PhD, Funding: Total Direct Costs: $863,900 (Total Costs: $1,345,590); Overall Aims: In this project, we will test the hypothesis that men with chronic pelvic pain have changes in resting brain function associated with changes in muscle control underlying the dysfunction in this disorder.
- Funding Source: The Charles D. and Mary Bauer Foundation; Dates: 09/2018-09/2020; Title: Optimization of Spinal Manual Therapy for Shoulder Pain; Principal Investigators: Lori Michener and Jason J. Kutch; Funding: $47,979; Overall Aims: Characterize the central nervous system mechanisms using brain imaging and identify predictors of a positive response to spinal manual therapy in patients with rotator cuff disease. The findings will optimize the delivery and treatment response to spinal manual therapy.
