How do the lungs respond to injury? How can we stimulate the lungs to regenerate effectively?
![](https://sites.usc.edu/huanglab/files/2024/02/research-32f554b5e108b9bf.png)
The Huang Lab focuses on the study of biological processes and signaling pathways that affect lung progenitor responses to injury, which may shed light on therapeutic targets for debilitating lung diseases that affect millions of people worldwide. We will integrate the use of human iPSCs-derived platforms with genetic mouse models to study how lung progenitors self-renew and transdifferentiate after lung injury, and why this process is dysregulated in diseases such as pulmonary fibrosis, chronic obstructive pulmonary disease, and lung adenocarcinoma.