Selected Publications

Year 2024

Jiang Y, Zhao H, Kong S, Zhou D, Dong J, Cheng Y, Zhang S, Wang F, Kalra A, Yang N, Wei DD, Chen J, Zhang YW, Lin DC (Correspondence), Meltzer SJ, Jiang YY. Establishing mouse and human oral esophageal organoids to investigate the tumor immune response. Dis Model Mech. 2024 Jan 1;17(1):dmm050319. doi: 10.1242/dmm.050319. Epub 2024 Jan 23.PMID: 38258518
Ziman B, Yang Q, Zheng Y, Sheth M, Nam C, Zhao H, Zhang L, Hu B, Bhowmick NA, Sinha UK, Lin DC*. Epigenomic analyses identify FOXM1 as a key regulator of anti-tumor immune response in esophageal adenocarcinoma. Cell Death Dis. 2024 Feb 19;15(2):152. PMID: 38373993
Jiang Y, Zheng Y, Zhang YW, Kong S, Dong J, Wang F, Ziman B, Gery S, Hao JJ, Zhou D, Zhou J, Ho AS, Sinha UK, Chen J, Zhang S, Yin C, Wei DD, Hazawa M, Pan H, Lu Z, Wei WQ, Wang MR, Koeffler HP, Lin DC*, Jiang YY. Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer. Nat Commun. 2024 Mar 20;15(1):2484. PMID: 38509096
Nam C, Li LY, Yang Q, Ziman B, Zhao H, Hu B, Collet C, Jing P, Lei Q, Xu LY, Li EM, Koeffler HP, Sinha UK, Lin DC*. A druggable cascade links methionine metabolism to epigenomic reprogramming in squamous cell carcinoma. Proc Natl Acad Sci USA. 2024 Jun 25;121(26):e2320835121. PMID: 38900797
Monreal AV, Zhao H, Sedghizadeh PP, Lin DC*. “Patient-derived tumor organoids to model drug response in Gastric Cancer.” Cell Reports Medicine, vol. 5, no. 7, 16 July 2024, p. 101650, https://doi.org/10.1016/j.xcrm.2024.101650.

Year 2023

Park, Y.M., Lin DC (Correspondence). Moving closer towards a comprehensive view of tumor biology and microarchitecture using spatial transcriptomics. Nature Communications 14, 7017 (2023). https://doi.org/10.1038/s41467-023-42960-6
Ho AS, Luu M, Balzer BL, Aro K, Jang JK, Mita AC, Scher KS, Mallen-St Clair J, Vasquez M, Bastien AJ, Epstein JB, Lin DC, Chen MM, Zumsteg ZS. Comparative impact of grade on mortality across salivary cancers: A novel, unifying staging system. Head Neck. 2023 Aug;45(8):2028-2039. doi: 10.1002/hed.27429. Epub 2023 Jun 22. PMID: 37345665
Zheng Y, Ziman B, Ho AS, Sinha UK, Xu LY, Li EM, Koeffler HP, Berman BP, Lin DC (Correspondence). Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation. Genome Biol. 2023 Aug 24;24(1):193. doi: 10.1186/s13059-023-03035-3. PMID: 37620896
Sinha UK, Lin DC. A novel role of master regulator transcription factor in anti-tumor immunity and cancer immunotherapy. Theranostics 2023; 13(6):1823-1825. doi:10.7150/thno.83486.
Lin, D.-C (Correspondence). Large-scale genomic analyses reveal alterations and mechanisms underlying clonal evolution and immune evasion in esophageal cancer. Nature Communications. Feb 17; (2023) 14:893
Ran XB, Ding LW, Sun QY, Yang H, Said JW, Zhentang L, Madan V, Dakle P, Xiao JF, Loh X, Li Y, Xu L, Xiang XQ, Wang LZ, Goh BC, Lin DC, Chng WJ, Tan SY, Jha S, Koeffler HP. Targeting RNA exonuclease XRN1 potentiates efficacy of cancer immunotherapy. Cancer Res. 2023 Jan 13:CAN-21-3052. PMID: 36638333
Zhang L, Zheng Y, Chien W, Ziman B, Billet S, Koeffler HP, Lin DC (Correspondence), Bhowmick NA. ARID1A Deficiency Regulates Anti-Tumor Immune Response in Esophageal Adenocarcinoma. Cancers (Basel). 2023 Nov 12;15(22):5377. doi: 10.3390/cancers15225377. PMID: 38001638
Hazawa M*, Ikliptikawati DK*, Iwashima Y*, Lin DC*, Jiang Y, Qiu Y, Makiyama K, Matsumoto K, Kobayashi A, Nishide G, Keesiang L, Yoshino H, Minamoto T, Suzuki T, Kobayashi I, Meguro-Horike M, Jiang YY, Nishiuchi T, Konno H, Koeffler HP, Hosomichi K, Tajima A, Horike SI, Wong RW. Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells. Cell Chem Biol. 2023 Oct 30:S2451-9456(23)00366-5. PMID: 37924814

Year 2022

1. H. Zhao, Y. Cheng, A. Kalra, K. Ma, Y. Zheng, B. Ziman, C. Tressler, K. Glunde, E. J. Shin, S. Ngamruengphong, M. Khashab, V. Singh, R. A. Anders, S. Jit, N. Wyhs, W. Chen, X. Li, D.-C. Lin (Correspondence), S. J. Meltzer, Generation and multiomic profiling of a TP53/CDKN2A double-knockout gastroesophageal junction organoid model. Sci Transl Med. 14 (2022), doi:10.1126/SCITRANSLMED.ABQ6146.
2. Sinha UK, Kast WM, Lin, D.-C (Correspondence). Single-cell genomics identifies immune response to neoadjuvant chemoradiotherapy. eBioMedicine. 2022 https://doi.org/10.1016/j.ebiom.2022.104371
3. Nam C, Ziman B, Sheth M, Zhao H, Lin, D.-C (Correspondence). Genomic and Epigenomic Characterization of Tumor Organoid Models. Cancers. 2022, 14, 4090. https://doi.org/10.3390/cancers14174090
4. Yueyuan Zheng, Benjamin Ziman, Allen S. Ho, Uttam K. Sinha, Li-Yan Xu, En-Min Li, Benjamin P. Berman, De-Chen Lin (Correspondence). Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation. bioRxiv 2022.08.18.504390; doi: https://doi.org/10.1101/2022.08.18.504390
5. Zhao H, Collet C, Peng D, Sinha UK, Lin, D.-C (Correspondence). Investigation of early neoplastic transformation and premalignant biology using genetically engineered organoid models. Computational and Structural Biotechnology Journal, 2022, https://doi.org/10.1016/j.csbj.2022.09.026
6. Dinh HQ, Pan F, Wang G, Huang QF, Olingy CE, Wu ZY, Wang SH, Xu X, Xu XE, He JZ, Yang Q, Orsulic S, Haro M, Li LY, Huang GW, Breunig JJ, Koeffler HP, Hedrick CC, Xu LY, Lin DC (Correspondence), Li EM. Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment. Nat Commun. 2021 Dec 17;12(1):7335. doi: 10.1038/s41467-021-27599-5.PMID: 3492116
7. Dror Bar, Lior Fishman, Yueyuan Zheng, Irene Unterman, Devorah Schlesinger, Amir Eden, De-Chen Lin (Correspondence), Benjamin P Berman. A local sequence signature defines a subset of heterochromatin-associated CpGs with minimal loss of methylation in healthy tissues but extensive loss in cancer. bioRxiv 2022.08.16.504069; doi: https://doi.org/10.1101/2022.08.16.504069
8. Nguyen AT, Luu M, Nguyen VP, Lu DJ, Shiao SL, Kamrava M, Atkins KM, Mita AC, Scher KS, Spratt DE, Faries MB, Daskivich TJ, Lin DC, Chen MM, Mallen-St Clair J, Sandler HM, Ho AS, Zumsteg ZS. Quantitative Nodal Burden and Mortality across Solid Cancers. J Natl Cancer Inst. 2022 Mar 21:djac059. doi: 10.1093/jnci/djac059. PMID: 35311991
9. Ho AS, Robinson A, Shon W, Laury A, Raedschelders K, Venkatraman V, Holewinski R, Zhang Y, Shiao SL, Chen MM, Mallen-St Clair J, Lin DC, Zumsteg ZS, Van Eyk JE. Comparative Proteomic Analysis of HPV(+) Oropharyngeal Squamous Cell Carcinoma Recurrence. J Proteome Res. 2022 Jan 7;21(1):200-208. PMID: 34846153

Year 2017-2021 (my first faculty position at Cedars-Sinai)

Lin DC (Correspondence). A closer look at esophageal cancer through different lenses. EBioMedicine. 2021 Aug 19;71:103545. PMID: 34419929
Li-Yan Li, Qian Yang, Yan-Yi Jiang, Wei Yang, Yuan Jiang, Xiang Li, Masaharu Hazawa, Bo Zhou, Guo-Wei Huang, Xiu-E Xu, Sigal Gery, Ying Zhang, Ling-Wen Ding, Allen S Ho, Zachary S Zumsteg, Ming-Rong Wang, Melissa J Fullwood, Stephen J Freedland, Stephen J Meltzer, Li-Yan Xu, En-Min Li, H Phillip Koeffler, Lin DC (Correspondence). Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer. Nat Commun, 2021 Jul 16;12(1):4362. doi: 10.1038/s41467-021-24656-x. PMID: 34272396.
Yuan Jiang, Yan-yi Jiang, Lin DC (Correspondence). Super-enhancer-mediated core regulatory circuitry in human cancer. Comput Struct Biotechnol J. 2021 May 5;19:2790-2795. doi:10.1016/j.csbj.2021.05.006. eCollection 2021. PMID: 34093993.
Zheng Y, G Huang, T Silva, Q Yang, Y Jiang, H.P. Koeffler, Lin DC (Correspondence), B. Berman, A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes. Nat commun, 2021 Apr 30. DOI: 10.1038/s41467-021-22720-0. PMID: 33931649
Ma S, Zhou B, Yang Q, Pan Y, Yang W, Freedland SJ, Ding LW, Freeman MR, Breunig JJ, Bhowmick NA, Pan J, Koeffler HP, Lin DC (Correspondence). A transcriptional regulatory loop of master regulator transcription factors, PPARG, and fatty acid synthesis promotes esophageal adenocarcinoma. Cancer Res. 2021 Jan 5 doi: 10.1158/0008-5472.CAN-20-0652. PMID: 33402390

Shi X, Zheng Y, Jiang L, Zhou B, Yang W, Li L, Ding L, Huang M, Gery S, Koeffler HP, Lin DC (Correspondence). EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma. Nucleic Acids Res. 2020 Oct 20. doi: 10.1093/nar/gkaa901. PMID: 33080033
Jiang YY, Jiang Y, Li CQ, Zhang Y, Dakle P, Kaur H, Deng JW, Yu-Tong Lin R, Han L, Xie JJ, Yan Y, Doan N, Zheng Y, Mayakonda A, Hazawa M, Xu L, Li Y, Aswad L, Jeitany M, Kanojia D, Guan XY, Said JW, Yang W, Fullwood MJ, Koeffler HP, Lin DC (Correspondence). TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines. Gastroenterology. 2020 Jun 30:S0016-5085(20)34854-X. doi: 10.1053/j.gastro.2020.06.050. PMID: 32619460
Wang QY, Peng L, Chen Y, Liao LD, Chen JX, Li M, Li YY, Qian FC, Zhang YX, Wang F, Li CQ, Lin DC (Correspondence), Xu LY, Li EM. Characterization of super-enhancer associated functional lncRNAs acting as ceRNAs in ESCC. Mol Oncol. 2020 May 27. doi: 10.1002/1878-0261.12726. PMID: 32460441
Pan J, Silva TC, Gull N, Yang Q, Plummer JT, Chen S, Daigo K, Hamakubo T, Gery S, Ding LW, Jiang YY, Hu S, Xu LY, Li EM, Ding Y, Klempner SJ, Gayther SA, Berman BP, Koeffler HP, Lin DC (Correspondence). Lineage-specific epigenomic and genomic activation of oncogene HNF4A promotes gastrointestinal adenocarcinomas. Cancer Res. 2020 Apr 24. doi: 10.1158/0008-5472.CAN-20-0390. PMID: 32332020
Huang M, Wang Y, Yang M, Yan J, Yang H, Zhuang W, Xu Y, Koeffler HP, Lin DC (Correspondence), Chen X. dbInDel: a database of enhancer-associated insertion and deletion variants by analysis of H3K27Ac ChIP-Seq. Bioinformatics. 2020 Mar 1;36(5):1649-1651. PMID: 31603498
Chen L, Huang M, Plummer J, Pan J, Jiang YY, Yang Q, Silva TC, Gull N, Chen S, Ding LW, An O, Yang H, Cheng Y, Said JW, Doan N, Dinjens WN, Waters KM, Tuli R, Gayther SA, Klempner SJ, Berman BP, Meltzer SJ, Lin DC (Correspondence), Koeffler HP. Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in oesophageal adenocarcinoma. Gut. 2020 Apr;69(4):630-640. PMID: 31409603
Loh XY, Sun QY, Ding LW, Mayakonda A, Venkatachalam N, Yeo MS, Silva TC, Xiao JF, B Doan N, W Said J, Ran XB, Zhou SQ, Dakle P, Shyamsunder P, Koh AP, Huang RY, P Berman B, Tan SY, Yang H, Lin DC, Koeffler HP. RNA-binding protein ZFP36L1 suppresses hypoxia and cell cycle signaling. Cancer Res. 2020 Jan 15;80(2):219-233. PMID: 31551365
Hazawa M, Sakai K, Kobayashi A, Yoshino H, Iga Y, Iwashima Y, Lim KS, Chih-Cheng Voon D, Jiang YY, Horike SI, Lin DC (Correspondence), Wong RW. Disease-specific alteration of karyopherin-α subtype establishes feed-forward oncogenic signaling in head and neck squamous cell carcinoma. Oncogene. 2020 Mar;39(10):2212-2223. PMID:31822798

Liao JY, Yang B, Zhang YC, Wang XJ, Ye Y, Peng JW, Yang ZZ, He JH, Zhang Y, Hu K, Lin DC (Correspondence), Yin D. EuRBPDB: a comprehensive resource for annotation, functional and oncological investigation of eukaryotic RNA binding proteins (RBPs). Nucleic Acids Res. 2019 Oct 10. doi: 10.1093/nar/gkz823. PMID: 31598693.
You R, Liu YP, Lin DC (Co-first), Li Q, Yu T, Zou X, Lin M, Zhang XL, He GP, Yang Q, Zhang YN, Xie YL, Jiang R, Wu CY, Zhang C, Cui C, Wang JQ, Wang Y, Zhuang AH, Guo GF, Hua YJ, Sun R, Yun JP, Zuo ZX, Liu ZX, Zhu XF, Kang TB, Qian CN, Mai HQ, Sun Y, Zeng MS, Feng L, Zeng YX, Chen MY. Clonal Mutations Activate the NF-κB Pathway to Promote Recurrence of Nasopharyngeal Carcinoma. Cancer Res. 2019 Sep 4. doi: 10.1158/0008-5472.CAN-18-3845. PMID:31484669
Chen F, Chen J, Yang L, Liu J, Zhang X, Zhang Y, Tu Q, Yin D, Lin DC, Wong PP, Huang D, Xing Y, Zhao J, Li M, Liu Q, Su F, Su S, Song E. Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells. Nat Cell Biol. 2019 Apr;21(4):498-510. doi: 10.1038/s41556-019-0299-0. Epub 2019 Apr 1. PMID: 30936474
Ding LW, Sun QY, Edwards JJ, Fernández LT, Ran XB, Zhou SQ, Scolyer RA, Wilmott JS, Thompson JF, Doan N, Said JW, Venkatachalam N, Xiao JF, Loh XY, Pein M, Xu L, Mullins DW, Yang H, Lin DC, Koeffler HP. LNK suppresses interferon signaling in melanoma. Nat Commun. 2019 May 20;10(1):2230. doi: 10.1038/s41467-019-09711-y. PMID: 31110180
Sun QY, Ding LW, Johnson K, Zhou S, Tyner JW, Yang H, Doan NB, Said JW, Xiao JF, Loh XY, Ran XB, Venkatachalam N, Lao Z, Chen Y, Xu L, Fan LF, Chien W, Lin DC, Koeffler HP. SOX7 regulates MAPK/ERK-BIM mediated apoptosis in cancer cells. Oncogene. 2019 Jul 22. doi: 10.1038/s41388-019-0865-8. PMID:31332289

Lin L, Huang M, Shi X, Mayakonda A, Hu K, Jiang YY, Guo X, Chen L, Pang B, Doan N, Said JW, Xie J, Gery S, Cheng X, Lin Z, Li J, Berman BP, Yin D, Lin DC (Correspondence), Koeffler HP. Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1. Nucleic Acids Res. 2018 Nov 28. doi: 10.1093/nar/gky1207. PMID: 30496486
Silva TC, Coetzee SG, Gull N, Yao L, Hazelett DJ, Noushmehr H, Lin DC (Correspondence), Berman BP. ELMER v.2: An R/Bioconductor package to reconstruct gene regulatory networks from DNA methylation and transcriptome profiles. Bioinformatics. 2018 Oct 26. doi: 10.1093/bioinformatics/bty902. PMID：30364927
Mayakonda A, Lin DC (Correspondence), Assenov Y, Plass C, Koeffler HP. Maftools: efficient and comprehensive analysis of somatic variants in cancer. Genome Res. 2018 Oct 19. doi: 10.1101/gr.239244.118. PMID: 30341162
Jiang Y, Jiang YY, Xie JJ, Mayakonda A, Hazawa M, Chen L, Xiao JF, Li CQ, Huang ML, Ding LW, Sun QY, Xu L, Kanojia D, Jeitany M, Deng JW, Liao LD, Soukiasian HJ, Berman BP, Hao JJ, Xu LY, Li EM, Wang MR, Bi XG, Lin DC (Correspondence), Koeffler HP. Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression. Nat Commun. 2018 Sep 6;9(1):3619. PMID: 30190462
Guo X, Zhang Y, Mayakonda A, Madan V, Ding LW, Lin LH, Zia S, Gery S, Tyner JW, Zhou W, Yin D, Lin DC (Correspondence), Koeffler HP. ARID1A and CEBPα cooperatively inhibit UCA1 transcription in breast cancer. Oncogene. 2018 Jul 6. doi: 10.1038/s41388-018-0371-4. PMID: 29980791
Xie J-J, Jiang Y-Y, Jiang Y, Li C-Q, Chee L-M, An O, Mayakonda A, Ding LW, Long L, Sun C, Lin L-H, Chen L, Wu J-Y, Wu Z-Y, Cao Q, Fang W-K, Yang W, Soukiasian H, Meltzer SJ, Yang H, Fullwood M, Xu L-Y, Li E-M, Lin DC (Correspondence), Koeffler HP. Super-Enhancer-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in Squamous Cell Carcinoma. Gastroenterology 2018 Jun;154(8):2137-2151. PMID: 29454790
Hazawa M, Lin DC (Co-first), Kobayashi A, Jiang YY, Xu L, Dewi FRP, Mohamed MS, Hartono, Nakada M, Meguro-Horike M, Horike SI, Koeffler HP, Wong RW. ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation. EMBO Rep. 2018 Jan;19(1):73-88. PMID: 29217659
Yuan J, Jiang YY, Mayakonda A, Huang M, Ding LW, Lin H, Yu F, Lu Y, Loh TKS, Chow M, Savage SL, Tyner JW, Lin DC (Correspondence), Koeffler HP. Super-enhancers promote transcriptional dysregulation in nasopharyngeal carcinoma. Cancer Res. 2017 Dec 1;77(23):6614-6626. PMID:28951465
Xiao JF, Sun QY, Ding LW, Chien W, Liu XY, Mayakanda A, Jiang YY, Loh XY, Ran XB, Doan NB, Castor B, Chia D, Said JW, Tan KT, Yang H, Fu XY, Lin DC, Koeffler HP. The MYC/BMI1 axis is essential for SETDB1-mediated breast tumorigenesis. J Pathol. 2018 Jun 21. doi: 10.1002/path.5126. PMID:29926931
Corces MR, Granja JM, Shams S, Louie BH, Seoane JA, Zhou W, Silva TC, Groeneveld C, Wong CK, Cho SW, Satpathy AT, Mumbach MR, Hoadley KA, Robertson AG, Sheffield NC, Felau I, Castro MAA, Berman BP, Staudt LM, Zenklusen JC, Laird PW, Curtis C; Cancer Genome Atlas Analysis Network (Lin DC), Greenleaf WJ, Chang HY. The chromatin accessibility landscape of primary human cancers. Science. 2018 Oct 26;362(6413). PMID:30361341

Lin DC (Correspondence), H Q. Dinh, J Xie, A Mayakonda, T Silva, YY Jiang, LW Ding, JZ He, XE Xu, J Hao, MR Wang, C Li, L Xu, E Li, B Berman, HP Koeffler. Identification of distinct mutational patterns and new driver genes in oesophageal squamous cell carcinomas and adenocarcinomas. Gut. 2017 Aug 31.doi:10.1136/gutjnl-2017-314607. PMID: 28860350
Lin DC (Correspondence), Wang MR, Koeffler HP. Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients. Gastroenterology. 2017 Jul 27. doi: 10.1053/j.gastro.2017.06.066. PMID: 28757263
Xu L, Chen Y, Dutra-Clarke M, Mayakonda A, Hazawa M, Savinoff SE, Doan N, Said JW, Yong WH, Watkins A, Yang H, Ding LW, Jiang YY, Tyner JW, Ching J, Kovalik JP, Madan V, Chan SL, Müschen M, Breunig JJ, Lin DC (Correspondence), Koeffler HP. BCL6 promotes glioma and serves as a therapeutic target. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3981-3986. PMID: 28356518
Sun H, Lin DC (Correspondence), Cao Q, Pang B, Gae DD, Lee VK, Lim HJ, Doan N, Said JW, Gery S, Chow M, Mayakonda A, Forscher C, Tyner JW, Koeffler HP. Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma. Clin Cancer Res 2017 Mar 23. doi: 10.1158/1078-0432.CCR-16-2185. PMID: 28336564
Lin DC (Correspondence), Mayakonda A, Dinh HQ, Huang P, Lin L, Liu X, Ding LW, Wang J, Berman B, Song E, Yin D, Koeffler HP. Genomic and epigenomic heterogeneity of hepatocellular carcinoma. Cancer Res Feb 20 2017. DOI:10.1158/ 0008- 5472.CAN-16-2822. PMID: 28302680
Hazawa M, Lin DC (Correspondence), Handral H, Xu L, Chen Y, Jiang YY, Mayakonda A, Ding LW, Meng X, Sharma A, Samuel S, Movahednia MM, Wong RW, Yang H, Tong C, Koeffler HP. ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma. Oncogene. 2017 Apr 20;36(16):2243-2254. PMID: 27819679
Zhao Z, Jia Q, Wu MS, Xie X, Wang Y, Song G, Zou CY, Tang Q, Lu J, Huang G, Wang J, Lin DC, Koeffler HP, Yin JQ, Shen J. Degalactotigonin, a natural compound from Solanum nigrum L., inhibits growth and metastasis of osteosarcoma through GSK3β inactivation-mediated repression of the Hedgehog/Gli1 pathway. Clin Cancer Res. 2017 Sep 26. doi: 10.1158/1078-0432.CCR-17-0692. PMID:28951519
Takao S, Chien W, Madan V, Lin DC, Ding LW, Sun QY, Mayakonda A, Sudo M, Xu L, Chen Y, Jiang YY, Gery S, Lill M, Park E, Senapedis W, Baloglu E, Müschen M, Koeffler HP. Targeting the vulnerability to NAD+ depletion in B-cell acute lymphoblastic leukemia. Leukemia. 2017 Sep 14. doi: 10.1038/leu.2017.281. PMID: 28904384
Cao Q, Zhao X, Bai J, Gery S, Sun H, Lin DC, Chen Q, Chen Z, Mack L, Yang H, Deng R, Shi X, Chong LW, Cho H, Xie J, Li QZ, Müschen M, Atkins AR, Liddle C, Yu RT, Alkan S, Said JW, Zheng Y, Downes M, Evans RM, Koeffler HP. Circadian clock cryptochrome proteins regulate autoimmunity. Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12548-12553. PMID: 29109286

Year 2016 and prior (when I was a postdoc)

Hao JJ, Lin DC (Correspondence), Dinh HQ, Mayakonda A, Jiang YY, Chang C, Jiang Y, Lu CC, Shi ZZ, Xu X, Zhang Y, Cai Y, Wang JW, Zhan QM, Wei WQ, Berman BP, Wang MR, Koeffler HP. Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma. Nat Genet. 2016 Dec;48(12):1500-1507. PMID: 27749841
Jiang YY, Lin DC (Correspondence), Mayakonda A, Hazawa M, Ding LW, Chien WW, Xu L, Chen Y, Xiao JF, Senapedis W, Baloglu E, Kanojia D, Shang L, Xu X, Yang H, Tyner JW, Wang MR, Koeffler HP. Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma. Gut. 2016 May 10. doi: 10.1136/gutjnl-2016-311818. PMID: 27196599
Sun H, Lin DC (Correspondence), Cao Q, Guo X, Marijon H, Zhao Z, Gery S, Xu L, Yang H, Pang B, Lee VK, Lim HJ, Doan N, Said JW, Chu P, Mayakonda A, Thomas T, Forscher C, Baloglu E, Shacham S, Rajalingam R, Koeffler HP. CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1–Dependent IGF-1 Signaling. Cancer Res. 2016 May 1;76(9):2687-97. PMID: 26956669
Lin DC (Correspondence), Xu L, Chen Y, Yan H, Hazawa M, Doan N, Said JW, Ding LW, Liu LZ, Yang H, Yu S, Kahn M, Yin D, Koeffler HP. Genomic and Functional Analysis of the E3 Ligase PARK2 in Glioma. Cancer Res. 2015 May 1;75(9):1815-27. PMID: 25877876
Lin DC (Correspondence), Hao JJ, Nagata Y, Xu L, Shang L, Meng X, Sato Y, Okuno Y, Varela AM, Ding LW, Garg M, Liu LZ, Yang H, Yin D, Shi ZZ, Jiang YY, Gu WY, Gong T, Zhang Y, Xu X, Kalid O, Shacham S, Ogawa S, Wang MR, Koeffler HP. Genomic and molecular characterization of esophageal squamous cell carcinoma. Nat Genet. 2014 May;46(5):467-73. PMID: 24686850
Lin DC (Correspondence), Meng X, Hazawa M, Nagata Y, Varela AM, Xu L, Sato Y, Liu LZ, Ding LW, Sharma A, Goh BC, Lee SC, Petersson BF, Yu FG, Macary P, Oo MZ, Ha CS, Yang H, Ogawa S, Loh KS, Koeffler HP. The genomic landscape of nasopharyngeal carcinoma. Nat Genet. 2014 Aug;46(8):866-71. PMID: 24952746
Lin DC (Correspondence), Xu L, Ding LW, Sharma A, Liu LZ, Yang H, Tan P, Vadgama J, Karlan BY, Lester J, Urban N, Schummer M, Doan N, Said JW, Sun H, Walsh M, Thomas CJ, Patel P, Yin D, Chan D, Koeffler HP. Genomic and Functional Characterizations of Phosphodiesterase 4D in Human Cancers. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6109-14. PMID: 23536305
Lin DC (Correspondence), Yin T, Koren-Michowitz M, Ding LW, Gueller S, Gery S, Tabayashi T, Bergholz U, Kazi JU, Rönnstrand L, Stocking C, Koeffler HP. Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3. Blood. 2012 Oct 18;120(16):3310-7. PMID: 22942183
Lin DC, Zhang Y, Pan QJ, Yang H, Shi ZZ, Xie ZH, Wang BS, Hao JJ, Zhang TT, Xu X, Zhan QM, Wang MR. PLK1 is transcriptionally activated by NF-Kappa B during cell detachment and enhances anoikis resistance through inhibiting Beta-catenin degradation in esophageal cancer. Clin Cancer Res; 17(13) July 1, 2011. PMID: 21610149
Lin DC (Correspondence), Wang MR and Koeffler HP. Targeting genetic lesions in esophageal cancer. Cell Cycle. 2014 Jun 5;13(13). PMID: 24901941
Xu L, Lin DC (Correspondence), Yin D and Koeffler HP. An emerging role of PARK2 in cancer. J Mol Med (Berl). 2014 Jan;92(1):31-42. PMID: 24297497
Sun QY, Ding LW, Xiao JF, Chien W, Lim SL, Hattori N, Goodglick L, Chia D, Mah V, Alavi M, Kim SR, Doan NB, Said JW, Loh XY, Xu L, Liu LZ, Yang H, Hayano T, Shi S, Xie D, Lin DC and Koeffler HP. SETDB1 accelerates tumorigenesis by regulating WNT signaling pathway. J Pathol. 2014 Nov 18. doi: 10.1002/path.4482. PMID: 25404354
Ding LW, Sun QY, Lin DC, Chien W, Hattori N, Dong XM, Gery S, Garg M, Doan NB, Said JW, Xiao JF, Yang H, Liu LZ, Meng X, Huang RY, Tang K, Koeffler HP. LNK (SH2B3): paradoxical effects in ovarian cancer. Oncogene. 2014 Apr 7. doi: 10.1038/onc.2014.34. PMID: 24704825
Zhang Y, Du XL, Wang CJ, Lin DC, Ruan X, Feng YB, Huo YQ, Peng H, Cui JL, Zhang TT, Wang YQ, Zhang H, Zhan QM, Wang MR. Reciprocal activation between PLK1 and Stat3 contributes to survival and proliferation of esophageal cancer cells. Gastroenterology. 2012 Mar;142(3):521-530. PMID: 22108192
Shi ZZ, Shang L, Jiang YY, Hao JJ, Zhang Y, Zhang TT, Lin DC, Liu SG, Wang BS, Gong T, Zhan QM, Wang MR. Consistent and differential genetic aberrations between esophageal dysplasia and squamous cell carcinoma detected by array comparative genomic hybridization. Clin Cancer Res. 2013 Nov 1;19(21):5867-78. PMID: 24009147
Garg M, Nagata Y, Kanojia D, Mayakonda A, Yoshida K, Haridas Keloth S, Zang ZJ, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ding LW, Alpermann T, Sun QY, Lin DC, Chien W, Madan V, Liu LZ, Tan KT, Sampath A, Venkatesan S, Inokuchi K, Wakita S, Yamaguchi H, Chng WJ, Kham SK, Yeoh AE, Sanada M, Schiller J, Kreuzer KA, Kornblau SM, Kantarjian HM, Haferlach T, Lill M, Kuo MC, Shih LY, Blau IW, Blau O, Yang H, Ogawa S, Koeffler HP. Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse. Blood. 2015 Nov 26;126(22):2491-501. PMID: 26438511
Cao Q, Gearhart MD, Gery S, Shojaee S, Yang H, Sun H, Lin DC, Bai JW, Mead M, Zhao Z, Chen Q, Chien WW, Alkan S, Alpermann T, Haferlach T, Müschen M, Bardwell VJ, Koeffler HP. BCOR regulates myeloid cell proliferation and differentiation. Leukemia. 2016 Feb 5. doi: 10.1038/leu.2016.2. PMID: 26847029
Sun QY, Ding LW, Tan KT, Chien W, Mayakonda A, Lin DC, Loh XY, Xiao JF, Meggendorfer M, Alpermann T, Garg M, Lim SL, Madan V, Hattori N, Nagata Y, Miyano S, Yeoh AE, Hou HA, Jiang YY, Takao S, Liu LZ, Tan SZ, Lill M, Hayashi M, Kinoshita A, Kantarjian HM, Kornblau SM, Ogawa S, Haferlach T, Yang H, Koeffler HP. Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD). Leukemia. 2016 Jul 8. doi: 10.1038/leu.2016.160. PMID: 27389053
Ding LW, Ikezoe T, Tan KT, Mori M, Mayakonda A, Chien W, Lin DC, Jiang YY, Lill M, Yang H, Sun QY, Koeffler HP. Mutational profiling of a MonoMAC syndrome family with GATA2 deficiency. Leukemia. 2016 Sep 29. doi: 10.1038/leu.2016.256. PMID: 27680514
Ding L, Sun QY, Tan KT, Chien W, Thippeswamy AM, Eng Juh AY, Kawamata N, Nagata Y, Xiao JF, Loh XY, Lin DC, Garg M, Lim SL, Liu LZ, Madan V, Jiang YY, Xu L, Sanada M, Fernández LT, Preethi H, Lill M, Kantarjian H, Kornblau SM, Miyano S, Ogawa S, Liang DC, Shih LY, Yang H, Koeffler HP. Mutational landscape of pediatric acute lymphoblastic leukemia. Cancer Res. 2016 Nov 21. pii: canres.1303.2016. PMID: 27872090

Selected Publications

Year 2024

Year 2023

Year 2022

Year 2017-2021 (my first faculty position at Cedars-Sinai)

Year 2016​ and prior (when I was a postdoc)

Year 2016 and prior (when I was a postdoc)