Publications

1. Fangzhou Bian, Victoria Hansen, Hong Colleen Feng, Jingyu He, Yanshi Chen, Kaining Feng, Brenda Ebrahimi, Ryan S Gray, Yang Chai, Chia-Lung Wu, Zhaoyang Liu. The G protein-coupled receptor ADGRG6 maintains mouse growth plate homeostasis through IHH Signaling. J Bone Miner Res. 2024 Sep 5:zjae144. doi: 10.1093/jbmr/zjae144. Preprint: https://www.biorxiv.org/content/10.1101/2023.09.21.558739v1
2. Wang L*, Liu Z*⁺, Zhao S*, Xu K, Aceves V, Troutwine B, Liu L, Ma S, Qiu C, Niu Y, Wang S, Li X, Zhao L, Liu X, Wu Z, Zhang JT⁺, Gray RS⁺, Wu N⁺. Variants in the SOX9 internal transactivation domain reduce protein stability and induce axial skeleton dysplasia and scoliosis. (Under revision at PNAS) (* Authors contributed equally; ⁺ Corresponding Author.) Preprint: https://www.medrxiv.org/content/10.1101/2023.05.29.23290174v1
3. Liu Z, Hussien AA, Wang Y, Heckmann T, Gonzalez R, Karner CM, Snedeker JG, Gray RS. An adhesion G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment. Elife. 2021 Jul 28;10:e67781. doi: 10.7554/eLife.67781. PMID: 34318745; PMCID: PMC8328515.
4. Makki N, Zhao J, Liu Z, Eckalbar WL, Ushiki A, Khanshour AM, Wu J, Rios J, Gray RS, Wise CA, Ahituv N. Genomic characterization of the adolescent idiopathic scoliosis-associated transcriptome and regulome. Hum Mol Genet. 2021 Jan 21;29(22):3606-3615. doi: 10.1093/hmg/ddaa242. PMID: 33179741; PMCID: PMC7823110.
5. Liu Z, Easson GWD, Zhao J, Makki N, Ahituv N, Hilton MJ, Tang SY, Gray RS. Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice. PLoS Genet. 2019 Oct 25;15(10):e1008096. doi: 10.1371/journal.pgen.1008096. PMID: 31652254; PMCID: PMC6834287.
6. Liu Z, Ramachandran J, Vokes SA, Gray RS. Regulation of terminal hypertrophic chondrocyte differentiation in <i>Prmt5</i> mutant mice modeling infantile idiopathic scoliosis. Dis Model Mech. 2019 Dec 17;12(12):dmm041251. doi: 10.1242/dmm.041251. PMID: 31848143; PMCID: PMC6955203. (Cover Article)
7. Ramachandran J*, Liu Z*, Gray RS, Vokes SA. PRMT5 is necessary to form distinct cartilage identities in the knee and long bone. Dev Biol. 2019 Dec 15;456(2):154-163. doi: 10.1016/j.ydbio.2019.08.012. Epub 2019 Aug 20. PMID: 31442442; PMCID: PMC6884688. (* Authors contributed equally)
8. Zheng Y, Liu C, Ni L, Liu Z, Mirando AJ, Lin J, Saijilafu, Chen D, Hilton MJ, Li B, Chen J. Cell type-specific effects of Notch signaling activation on intervertebral discs: Implications for intervertebral disc degeneration. J Cell Physiol. 2018 Jul;233(7):5431-5440. doi: 10.1002/jcp.26385. Epub 2018 Jan 19. PMID: 30025440; PMCID: PMC6092956.
9. Dar QA, Schott EM, Catheline SE, Maynard RD, Liu Z, Kamal F, Farnsworth CW, Ketz JP, Mooney RA, Hilton MJ, Jonason JH, Prawitt J, Zuscik MJ. Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis. PLoS One. 2017 Apr 6;12(4):e0174705. doi: 10.1371/journal.pone.0174705. PMID: 28384173; PMCID: PMC5383229.
10. Li QQ*, Liu Z*, Lu W, Liu M. Interplay between Alternative Splicing and Alternative Polyadenylation Defines the Expression Outcome of the Plant Unique OXIDATIVE TOLERANT-6 Gene. Sci Rep. 2017 May 17;7(1):2052. doi: 10.1038/s41598-017-02215-z. PMID: 28515442; PMCID: PMC5435732. (* Authors contributed equally)
11. Liu Z, Ren Y, Mirando AJ, Wang C, Zuscik MJ, O’Keefe RJ, Hilton MJ. Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance. Osteoarthritis Cartilage. 2016 Apr;24(4):740-51. doi: 10.1016/j.joca.2015.10.015. Epub 2015 Oct 30. PMID: 26522700; PMCID: PMC4799757.
12. Wang C, Inzana JA, Mirando AJ, Ren Y, Liu Z, Shen J, O’Keefe RJ, Awad HA, Hilton MJ. NOTCH signaling in skeletal progenitors is critical for fracture repair. J Clin Invest. 2016 Apr 1;126(4):1471-81. doi: 10.1172/JCI80672. Epub 2016 Mar 7. PMID: 26950423; PMCID: PMC4811137.
13. Liu Z, Chen J, Mirando AJ, Wang C, Zuscik MJ, O’Keefe RJ, Hilton MJ. A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. Sci Signal. 2015 Jul 21;8(386):ra71. doi: 10.1126/scisignal.aaa3792. PMID: 26198357; PMCID: PMC4607068. (Cover Article)
14. Kohn A, Rutkowski TP, Liu Z, Mirando AJ, Zuscik MJ, O’Keefe RJ, Hilton MJ. Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9. Bone Res. 2015 Aug 11;3:15021. doi: 10.1038/boneres.2015.21. PMID: 26558140; PMCID: PMC4640428.
15. Mirando AJ*, Liu Z*, Moore T, Lang A, Kohn A, Osinski AM, O’Keefe RJ, Mooney RA, Zuscik MJ, Hilton MJ. RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance. Arthritis Rheum. 2013 Oct;65(10):2623-33. doi: 10.1002/art.38076. PMID: 23839930; PMCID: PMC4038327. (* Authors contributed equally)
16. Zhou J, Gao Y, Zhang Z, Zhang Y, Maltby KM, Liu Z, Lan Y, Jiang R. Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field. Dev Biol. 2011 May 15;353(2):344-53. doi: 10.1016/j.ydbio.2011.03.012. Epub 2011 Mar 17. PMID: 21420399; PMCID: PMC3081931.
17. Liu K XS, Xuan W, Ling T, Cao Z, Huang B, Sun Y, Fang L, Liu Z, Zhao N, Shen W. Carbon monoxide counteracts the inhibition of seed germination and alleviates oxidative damage caused by salt stress in Oryza sativa. Plant Sci. 2007;172:544-55.
18. Cao Z XW, Liu Z, Li X, Zhao N, Xu P, Wang Z, Guan R, Shen W. Carbon monoxide promotes lateral root formation in rapeseed. J Integr Plant Biol. 2007;49(7):1007-16.