Engineering Microphysiological Systems for Modeling Human Muscle Development and Disease
- We design and fabricate devices to systematically engineer cells into microtissues with controlled microenvironments and access to precise molecular and physiological measurements.
- Our core expertise is in cardiac muscle, but we also extend our toolkit to skeletal muscle, uterine smooth muscle, and other non-muscle tissues through collaborations.
- We use our models to elucidate fundamental insights into the role of cell-cell / cell-matrix interactions and mechanotransduction in human tissue development and disease.