55. Khalil NN, Rexius-Hall ML, Gupta D, McCarty L, Verma R, Kellogg A, Takamoto K, Xu M, Nejatopor T, Parker SJ, McCain ML. Hypoxic–Normoxic Crosstalk Activates Pro-Inflammatory Signaling in Human Cardiac Fibroblasts and Myocytes in a Post-Infarct Myocardium on a Chip. Advanced Healthcare Materials. 2024; e2401478. Link.
54. Garibyan M†, Hoffman T†, Makaske T, Do SK, March AR, Cho N, Pedroncelli N, Lima RE, Soto J, Jackson BA, Khademhosseini A, Li S, McCain ML, Morsut L. Engineering programmable material-to-cell pathways via synthetic notch receptors to spatially control differentiation in multicellular constructs. Nature Communications. 2024; 15(1): 5891.†Contributed equally Link.
53. Khalil NN, Rexius-Hall ML, Escopete S, Parker SJ, McCain ML. Distinct phenotypes induced by acute hypoxia and TGF-β1 in human adult cardiac fibroblasts. Journal of Molecular and Cellular Cardiology Plus. 25 June 2024. Link.
52. Bakis I, Sun Y, Elmagid LA, Feng X, Garibyan M, Yip JK, Yu FZ, Chowdhary S, Fernandez GE, Cao J, McCain ML, Lien C-L, Harrison MRM. Methods for dynamic and whole volume imaging of the zebrafish heart. Developmental Biology. 01 Dec 2023. Link.
51. Maxey AP, Travis JM, McCain ML. Regulation of oxytocin-induced calcium transients and gene expression in engineered myometrial tissues by tissue architecture and matrix rigidity. Current Research in Physiology. 21 Sept 2023. Part of Special Issue: Reproductive Engineering. Link.
50. Khalil NN*, Petersen AP*, Song CJ, Chen Y, Takamoto K, Kellogg AC, Chen EZ, McMahon AP, McCain ML. User-friendly microfluidic system reveals native-like morphological and transcriptomic phenotypes induced by shear stress in proximal tubule epithelium. APL Bioengineering. 07 Aug 2023. Link.*Contributed equally,
49. Rexius-Hall ML, Khalil NN, Escopete SS, Li X, Hu J, Yuan H, Parker SJ, McCainML. A myocardial infarct border-zone-on-a-chip demonstrates distinct regulation of cardiac tissue function by an oxygen gradient. Science Advances. 2022 Dec 7. Link.
48. Petersen AP, McCain ML. Quantifying propagation velocity from engineered cardiac tissues with high-speed fluorescence microscopy and automated analysis software. Methods in Molecular Biology: Cardiac Tissue Engineering Methods and Protocols. 2022;2485:133-145. Invited chapter.
47. Barthélémy F, Santoso JW, Rabichow L, Jin R, Little I, Nelson SF, McCain ML, Miceli MC. Modeling patient-specific muscular dystrophy phenotypes and therapeutic responses in reprogrammed myotubes engineered on micromolded gelatin hydrogels. Front. Cell Dev. Biol. 10: 830415. *Contributed equally, †co-corresponding authors. Link.
46. Kapuria S, Bai H, Fierros J, Huang Y, Ma F, Yoshida T, Aguayo A, Kok F, Wiens KM, Yip JK, McCain ML, Pellegrini M, Nagashima M, Hitchcock PF, Mochizuki N, Lawson ND, Harrison MMR, Lien CL. Heterogeneous pdgfrβ+ cells regulate coronary vessel development and revascularization during heart regeneration. Development. 2022 Jan 28:dev.199752. Link.
45. Santoso JW, Li X, Gupta D, Suh GC, Hendricks E, Lin S, Perry S, Ichida JK, Dickman D, McCain ML. Engineering skeletal muscle tissues with advanced maturity improves synapse formation with human induced pluripotent stem cell-derived motor neurons. APL Bioengineering. 2021 Jul 13;5(3):036101. Link.
44. Khalil NN, McCain ML. Engineering the cellular microenvironment of post-infarct myocardium on a chip. Front Cardiovasc Med. 2021 Jul 14;8:709871. Invited review. Link.
43. Yip JK*, Sarkar D*, Petersen AP, Gipson J, Tao J, Kale S, Rexius-Hall ML, Cho N, Khalil NN, Kapadia R†, McCain ML†. Contact Photolithography-Free Integration of Patterned and Semi-Transparent Indium Tin Oxide Stimulation Electrodes into Polydimethylsiloxane-Based Heart-on-a-Chip Devices for Streamlining Physiological Recordings. Lab on a Chip. 2021 (4), 674-687. *Contributed equally, †co-corresponding authors. Link.
42. Maxey AP, McCain ML. Tools, techniques, and future opportunities for characterizing the mechanobiology of uterine myometrium. Experimental Biology and Medicine. 2021 May;246(9):1025-1035. Invited review. Link.
41. Gupta D, Santoso JW, McCain ML. Characterization of gelatin hydrogels cross-linked with microbial transglutaminase as engineered skeletal muscle substrates. Bioengineering (Basel). 2021 Jan 6;8(1):6. Link.
40. Rexius-Hall ML, Ariyasinghe NR, McCain ML. Engineering shape-controlled microtissues on compliant hydrogels with tunable rigidity and extracellular matrix ligands. Methods in Molecular Biology: Programmed Morphogenesis. 2021;2258:57-72. Link.
39. Lyra-Leite DM, Petersen AP, Ariyasinghe NR, Cho N, McCain ML. Mitochondrial architecture in cardiac myocytes depends on cell shape and matrix rigidity. Journal of Molecular and Cellular Cardiology. 2020 Oct 8;150:32-43. Link.
38. Ariyasinghe NR*, Santoso JW*, Gupta D, Pincus MJ, August PR, McCain ML. Optical clearing of skeletal muscle bundles engineered in 3-D printed templates. Annals of Biomedical Engineering. 2020 Aug 3. *Contributed equally. Link.
37. Santoso JW, McCain ML. Neuromuscular disease modeling on a chip. Disease Models & Mechanisms. 2020 13: dmm044867. Invited review. Link.
36. Rexius-Hall ML, Khalil NK, Andres AA, McCain ML. Mitochondrial division inhibitor 1 (mdivi‐1) increases oxidative capacity and contractile stress generated by engineered skeletal muscle. The FASEB Journal. 2020 Jul 11. Link.
35. Petersen AP, Cho N, Lyra-Leite DM, Santoso JW, Gupta D, Ariyasinghe NR, McCain ML. Regulation of calcium dynamics and propagation velocity by tissue microstructure in engineered strands of cardiac tissue. Integrative Biology. 2020 Mar 6;12(2):34-46. Link.
34. Yip JK, Harrison M, Villafuerte J, Fernandez EG, Petersen AP, Lien CL, McCain ML. Extended culture and imaging of normal and regenerating adult zebrafish hearts in a fluidic device. Lab on a Chip. 2020;20:274-284. Link.
33. Lyra-Leite DM, Andres AM, Cho N, Petersen AP, Ariyasinghe NR, Kim SS, Gottlieb RA, McCain ML. Matrix-guided control of mitochondrial function in cardiac myocytes. Acta Biomaterialia. 2019 Oct 1;97:281-295. Link.
32. Ariyasinghe NR*, Lyra-Leite DM*, McCain ML. Engineering cardiac microphysiological systems to model pathological extracellular matrix remodeling. American Journal of Physiology – Heart and Circulatory Physiology. 2018 Oct 1;315(4):H771-H789. Invited review. Link. *Contributed equally.
31. Petersen AP, Lyra-Leite DM, Ariyasinghe NR, Cho N, Goodwin CM, Kim JY, McCain ML. Microenvironmental modulation of calcium wave propagation velocity in engineered cardiac tissues. Cellular and Molecular Bioengineering. 2018 Oct;11(5):337-352. Selected for the 2018 CMBE Young Innovators Special Issue.Link.
30. Yip JK, McCain ML. Cardiac Tissue Models. In: Microfluidic Cell Culture Systems, 2nd edition. Ed. Jeffrey Borenstein, Joe Charest, Sarah Tao, Vishal Tandon. Elsevier. 2019:209-248. Book chapter. Link.
29. Cho N, Razipour SE, McCain ML. TGF-β1 dominates extracellular matrix rigidity for inducing differentiation of human cardiac fibroblasts to myofibroblasts. Experimental Biology and Medicine. 2018 Apr;243(7):601-612. Featured Article. Link.
28. Lyra-Leite DM, Andres AM, Petersen AP, Ariyasinghe NR, Cho N, Lee JA, Gottlieb RA, McCain ML. Mitochondrial function in engineered cardiac tissues is co-regulated by extracellular matrix elasticity and tissue alignment. American Journal of Physiology – Heart and Circulatory Physiology. 2017 Oct 1;313(4):H757-67. Link.
27. Ariyasinghe NR, Reck CH, Viscio AA, Petersen AP, Lyra-Leite DM, Cho N, McCain ML. Engineering microMyocardium to delineate cellular and extracellular regulation of myocardial tissue contractility. Integrative Biology. 2017;9:730-41. Selected for cover image.Link.
26. Suh GC*, Bettadapur A*, Santoso JW, McCain ML. Fabrication of micromolded gelatin hydrogels for long-term culture of aligned skeletal myotubes. Methods in Molecular Biology: Skeletal Muscle Development. 2017;1668:147-63. *Contributed equally. Link.
25. McCain ML. Heart-on-a-Chip. In: Regenerative Medicine Technology: On-a-chip Applications for Disease Modeling, Drug Discovery and Personalized Medicine, 1st edition. Ed. Sean V. Murphy, Anthony Atala. CRC Press. 2016 Dec 13. Book chapter. Link.
24. Bettadapur A*, Suh GC*, Geisse NA, Wang ER, Hua C, Huber HA, Viscio AA, Kim JY, Strickland JB, McCain ML. Prolonged culture of aligned skeletal myotubes on micromolded gelatin hydrogels. Scientific Reports. 2016 Jun 28;6:28855. *Contributed equally. Link.
23. Knight MB, Grosberg A, McCain ML. In vitro tools for quantifying structure–function relationships in cardiac myocyte cells and tissues. In: Cardiac Cytoarchitecture: How to Maintain a Working Heart. Ed. Elisabeth Ehler. Springer International Publishing. 2015 Mar 3. Book chapter. Link.
22. McCain ML, Desplantez T, Kleber AG. Engineering cardiac cell junctions in vitro to study the intercalated disc. Cell Communication and Adhesion. 2014 Jun;21(3):181-91. Review. Link.
Prior to USC
21. Sheehy SP, Grosberg A, Qin P, Behm DJ, Ferrier JP, Eagleson MA, Nesmith AP, Krull D, Falls JG, Campbell PH, McCain ML, Willette RN, Hu E, Parker KK. Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes. Experimental Biology and Medicine. 2017 Jan 1: 1535370217701006.
20. Aratyn-Schaus Y*, Pasqualini FS*, Yuan H, McCain ML, Ye GJC, Sheehy SP, Campbell PH, Parker KK. Coupling primary and stem cell–derived cardiomyocytes in an in vitro model of cardiac cell therapy. Journal of Cell Biology. 2016 Feb 15;212(4):389-97. *Contributed equally.
19. Horton RE, Yadid M, McCain ML, Sheehy SP, Pasqualini FS, Park SJ, Cho A, Campbell P, Parker KK. Angiotensin II Induced Cardiac Dysfunction on a Chip. PLoS One. 2016 Jan 25;11(1):e0146415.
18. Lee H, Adams WJ, Alford PW, McCain ML, Feinberg AW, Sheehy SP, Goss JA, Parker KK. Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes. Experimental Biology and Medicine. 2015 Nov;240(11):1543-54.
17. Nesmith AP, Agarwal A, McCain ML, Parker KK. Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation. Lab on a Chip. 2014 Oct 21;14(20):3925-36.
16. Wang G*, McCain ML*, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK, Pu WT. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nature Medicine. 2014 Jun;20(6):616-23. *Contributed equally.
15. McCain ML, Agarwal A, Nesmith HW, Nesmith AP, Parker KK. Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues. Biomaterials. 2014 Jul;35(21)5462-71.
14. McCain ML*, Yuan H*, Pasqualini FS, Campbell PH, Parker KK. Matrix elasticity regulates the optimal cardiac myocyte shape for contractility. American Journal of Physiology – Heart and Circulatory Physiology. 2014 Jun 1;306(11):H1525-39. *Contributed equally.
13. Agarwal A, Goss JA, Cho A, McCain ML, Parker KK. Microfluidic heart on a chip for higher throughput pharmacological studies. Lab on a Chip. 2013 Sep 21;13(18):3599-608.
12. Agarwal A, Farouz Y, Nesmith AP, Deravi LF, McCain ML, Parker KK. Micropatterning alginate substrates for in vitro cardiovascular muscle on a chip. Advanced Functional Materials. 2013 Aug 12;23(30):3738-46.
11. McCain ML, Sheehy SP, Grosberg A, Goss JA, Parker KK. Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip. Proceedings of the National Academy of Sciences. 2013 Jun 11;110(24):9770-5.
10. Nawroth JC, Lee H, Feinberg AW, Ripplinger CM, McCain ML, Grosberg A, Dabiri JO, Parker KK.A tissue-engineered jellyfish with biomimetic propulsion. Nature Biotechnology. 2012 Aug;30(8):792-7.
9. McCain ML, Lee H, Aratyn-Schaus Y, Kléber AG, Parker KK.Cooperative coupling of cell-matrix and cell-cell adhesions in cardiac muscle. Proceedings of the National Academy of Sciences. 2012 Jun 19;109(25):9881-6.
8. Grosberg A, Nesmith AP, Goss JA, Brigham MD, McCain ML, Parker KK. Muscle on a chip: in vitro contractility assays for smooth and striated muscle. Journal of Pharmacological and Toxicololgical Methods. 2012 May-Jun;65(3):126-35.
7. Beauchamp P, Desplantez T, McCain ML, Li W, Asimaki A, Rigoli G, Parker KK, Saffitz JE, Kleber AG. Electrical coupling and propagation in engineered ventricular myocardium with heterogeneous expression of connexin43. Circulation Research. 2012 May 25;110(11):1445-53.
6. Desplantez T, McCain ML, Beauchamp P, Rigoli G, Rothen-Rutishauser B, Parker KK, Kleber AG. Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current. Cardiovascular Research. 2012 Apr 1;94(1):58-65.
5. McCain ML, Desplantez T, Geisse NA, Rothen-Rutishauser B, Oberer H, Parker KK, Kleber AG.Cell-to-cell coupling in engineered pairs of rat ventricular cardiomyocytes: relation between Cx43 immunofluorescence and intercellular electrical conductance. American Journal of Physiology – Heart and Circulatory Physiology. 2012 Jan;302(2):H443-50.
4. Grosberg A, Alford PW, McCain ML, Parker KK. Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip. Lab on a Chip. 2011 Dec 21;11(24):4165-73.
3. McCain ML, Parker KK. Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function. Pfluegers Archiv – European Journal of Physiology. 2011 Jul;462(1):89-104. Review.
2. Hucker WJ, McCain ML, Laughner JI, Iaizzo PA, Efimov IR. Connexin 43 expression delineates two discrete pathways in the human atrioventricular junction. The Anatomical Record. 2008 Feb;291(2):204-15.
1. Biragyn A, Schiavo R, Olkhanud P, Sumitomo K, King A, McCain M, Indig FE, Almanzar G, Baatar D. Tumor-associated embryonic antigen-expressing vaccines that target CCR6 elicit potent CD8+ T cell-mediated protective and therapeutic antitumor immunity. Journal of Immunology. 2007 Jul 15;179(2):1381-8