Our lab investigates the cellular and molecular foundations of the developing human brain under conditions of health, stress, and disease. We employ human induced pluripotent stem cell-based organoids, assembloids, induced neurons/neural crest cell models, as well as related animal models (e.g., mouse models). These are combined with advanced genetic/genomics techniques at the functional and single-cell levels. Our aim is to expand our knowledge of the cell-cell communication, fate dynamics, and niche homeostasis of the non-neuronal cells in health and emergency rescue when they are under stress or in disease. Ultimately, our collective efforts, alongside those of others in the field, will pave the way for groundbreaking interventions in the realm of pediatric disease.

We focus on the following perspectives:

• Demonstrating the roles of non-neuronal cells in developing human brain and related disorders.
• Dissecting the roles of environmental factors in brain disorders and their interactions with genetic alterations.
• Revealing the roles of the nervous system in pediatric tumors within and beyond the brain.

In our lab, we value collaboration, open communication, and work-life balance. We believe the most creative and impactful work arises from a healthy, supportive, and joyful environment where everyone can flourish. We challenge and support each other to conduct innovative and impactful basic and translational science, aiming to contribute to human health. We’re glad you’re here.