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Stem Cell models for Pediatric Diseases

Center for Craniofacial Molecular Biology

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Gallery

 

COs generated from iPSCs A1 and A2 showed reduced size compared with controls at DIV28, 52 and 90. Scale bar: 400 µm and impraied morphology and cellular expression in patient COs
data showing patient brain organoids and mouse cerebral and cerebellar hemispheres
scRNA-seq from hBOs generated from multiple patients' iPSCs
iPSC induced pericytes
Immunostaining for anti-laminin-β1 and anti-GFAP colocalized with GFP+ PLCs in PCCOs
Light sheet fluorescence microscopy image of GFP positive PLCs invading COs and GFP positive PLC penetration into the CTIP2 positive cortical plate-like zone
Patient iPSC derived brain organoids
locations of different types of brain tumors diagram with silhouette of a child and lines pointing to different areas of the brain indicating common tumor areas
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