- Kim, H.S., Hariri, K., Zhang, X.N., Chen, L.C., Katz, B.B., Pei, H., Louie, S.G. and Zhang, Y. Synthesis of Site-Specific Fab-Drug Conjugates Using ADP-Ribosyl Cyclases. Protein Sci., 2024, 33, e4924. PMID: 38501590
- Yu, P.W., Kao, G., Dai, Z., Nasertorabi, F. and Zhang, Y. Rational Design of Humanized Antibody Inhibitors for Cathepsin S. Arch. Biochem. Biophys. 2024, 751, 109849. PMID: 38061628
- Kim, H.S. and Zhang, Y. Generation of Bispecific Antibodies by Functionalized Poly-ADP-Ribose Polymers. Curr. Protoc. 2023, 3, e958. PMID: 38147359
- Stephens, E.N., Zhang, X.N., Lam, A.T., Li, J., Pei, H., Louie, S.G., Wang, C.C.C. and Zhang, Y. A Ribose-Functionalized NAD+ with Versatile Activity for ADP-Ribosylation. Chem. Commun. 2023, 59, 13843-13846. PMID: 37921487
- Cheng, Q., Zhang, X.N., Li, J., Chen, J., Wang, Y. and Zhang, Y. Synthesis of Bispecific Antibody Conjugates Using Functionalized Poly-ADP-Ribose Polymers. Biochemistry, 2023, 62, 1138–1144. PMID: 36821831
- Cheng, Q., Zhang, X.N., Zhang, L., Chen, J., Wang, Y. and Zhang, Y. A Poly-ADP-Ribose Polymer-GCSF Conjugate. Biomacromolecules 2022, 23, 5267-5272. PMID: 36350184
- Cheng, Q., Dai, Z., Smbatyan, G., Epstein, A.L., Lenz, H.J. and Zhang, Y. Eliciting Anti-Cancer Immunity by Genetically Engineered Multifunctional Exosomes. Mol. Ther. 2022, 30, 3066-3077. PMID: 35746867
- Zhang, X.N., Lam, A.T., Cheng, Q., Courouble, V.V., Strutzenberg, T.S., Li, J., Wang, Y., Pei, H., Stiles, B.L., Louie, S.G., Griffin, P.R. and Zhang, Y. Discovery of an NAD + Analogue with Enhanced Specificity for PARP1. Chem. Sci., 2022, 13, 1982-1991. PMID: 35308855
- Li, J., Stephens, E. and Zhang, Y. Extracellular Vesicles in Tumor Immunotherapy. In Systemic Drug Delivery Strategies: Volume 2 of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy. Elsevier Science, 2021, 231-256. Link
- Dai, Z., Zhang, X.N., Cheng, Q., Fei, F., Hou, T., Li, J., Abdolvahabi, A., Watanabe, J., Pei, H., Smbatyan, G., Xie, J., Lenz, H.J., Louie, S.G. and Zhang, Y. Site-Specific Antibody-Drug Conjugates with Variable Drug-to-Antibody-Ratios for AML Therapy. J. Control. Release 2021, 336, 433-442. PMID: 34197861
- Lambeth, T.R., Dai, Z., Zhang, Y. and Julian, R.R. A Two-Trick Pony: Lysosomal Protease Cathepsin B Possesses Surprising Ligase Activity. RSC Chem. Biol. 2021, 2, 606-611. PMID: 34291207
- Lam, A.T., Zhang, X.N., Courouble, V.V., Strutzenberg, T.S., Pei, H., Stiles, B.L., Louie, S.G., Griffin, P.R. and Zhang, Y. A Bifunctional NAD+ for Profiling Poly-ADP-Ribosylation-Dependent Interacting Proteins. ACS Chem. Biol. 2021, 16, 389-396. PMID: 33524253
- Shi, X., Zhang, X.N., Chen, J., Cheng, Q., Pei, H., Louie, S.G. and Zhang, Y. A Poly-ADP-Ribose Polymer-Based Antibody-Drug Conjugate. Chem. Sci. 2020, 11, 9303-9308. PMID: 33623656
- Shi, X. and Zhang, Y. A Humanized Antibody Inhibitor for Cathepsin L. Protein Sci. 2020, 29, 1924-1930. PMID: 32683733
- Dai, Z., Zhang, X.N., Nasertorabi, F., Cheng, Q., Li, J., Katz, B.B., Smbatyan, G., Pei, H., Louie, S. G., Lenz, H.J., Stevens, R.C. and Zhang, Y. Synthesis of Site-Specific Antibody-Drug Conjugates by ADP-Ribosyl Cyclases. Sci. Adv. 2020, 6, eaba6752. PMID: 32537509
- Madern, J.M., Kim, R.Q., Misra, M., Dikic, I., Zhang, Y., Ovaa, H., Codee, J.D.C., Filippov, D.V. and van der Heden van Noort, G.J. Synthesis of Stable NAD+ Mimics as Inhibitors for the Legionella Pneumophila Phosphoribosyl Ubiquitinating Enzyme SdeC. ChemBioChem 2020, 21, 2903-2907. PMID: 32421893
- Park, M., Vaikari, V.P., Lam, A.T., Zhang, Y., Mackay, J.A. and Alachkar, H. Anti-FLT3 nanoparticles for acute myeloid leukemia: preclinical pharmacology and pharmacokinetics. J. Control. Release 2020, 324, 317-329. PMID: 32428520
- Dai, Z., Cheng, Q. and Zhang, Y. Rational Design of a Humanized Antibody Inhibitor of Cathepsin B. Biochemistry 2020, 59, 1420-1427. PMID:32212642
- Cheng, Q., Shi, X. and Zhang, Y. Reprogramming Exosomes for Immunotherapy. Methods Mol. Biol. 2020, 2097, 197–209. PMID:31776927
- Shi, X., Cheng, Q., Hou, T., Han, M., Smbatyan, G., Lang, J.E., Epstein, A.L., Lenz, H.J. and Zhang, Y. Genetically Engineered Cell-Derived Nanoparticles for Targeted Breast Cancer Immunotherapy. Mol. Ther. 2020, 28, 536–547. PMID:31843452
- Shi, X., Cheng, Q. and Zhang, Y. Reprogramming Extracellular Vesicles with Engineered Proteins. Methods 2020, 177, 95-102. PMID:31568822
- Zhang, X.N., Cheng, Q., Chen, J., Lam, A.T., Lu, Y., Dai, Z., Pei, H., Evdokimov, N.M., Louie, S.G. and Zhang, Y. A Ribose-Functionalized NAD+ with Unexpected High Activity and Selectivity for Protein Poly-ADP-Ribosylation. Nat. Commun. 2019, 10, 4196. PMID:31519936
- Zhang XN, Dai Z, Cheng Q and Zhang Y. Chemoenzymatic Preparation of 4′-Thioribose NAD. Curr. Protoc. Nucleic Acid Chem. 2019 PMID:30951610
- Cheng, Q., Shi, X., Han, M., Smbatyan, G., Lenz, H.J. and Zhang, Y. Reprogramming Exosomes as Nanoscale Controllers of Cellular Immunity. J. Am. Chem. Soc. 2018, 140, 16413–16417 PMID30452238
- Dai, Z., Zhang, X.N., Nasertorabi, F., Cheng, Q., Pei, H., Louie, S.G., Stevens, R.C. and Zhang, Y. Facile Chemoenzymatic Synthesis of a Novel Stable Mimic of NAD+. Chem. Sci. 2018, 9, 8337-8342 Featured in Front Cover PMC6256357
- Chen, J., Lam, A.T. and Zhang, Y. A Macrodomain-Linked Immunosorbent Assay (MLISA) for Mono-ADP-Ribosyltransferases. Anal Biochem., 2017, 543, 132-139. PMID29247608
- Du, J., Cao Y., Liu, Y., Wang, Y., Zhang, Y., Fu, G., Zhang, Y., Lu, L., Luo, X., Kim, C.H., Schultz, P.G. and Wang, F. Engineering Bifunctional Antibodies with Constant Region Fusion Architectures. J. Am. Chem. Soc., 2017, 139, 18607–18615. PMID29186655
- Liu, Y., Wang, Y., Zhang, Y., Liu, T., Jia, H., Zou, H., Fu, Q., Zhang, Y., Lu, L., Chao, E., Parker, H., Nguyen-Tran, V.T.B., Shen, W., Wang, D., Schultz, P.G. and Wang, F. Rational Design of Dual Agonist-Antibody Fusions as Long-Acting Therapeutic Hormones. ACS Chem. Biol., 2016, 11, 2991-2995. PMC5148668
- Luo, X., Wang, T.S.A., Zhang, Y., Wang, F. and Schultz, P.G. Stabilizing Protein Motifs with a Genetically Encoded Metal-Ion Chelator. Cell Chem. Biol., 2016, 23,1098-102. PMID27662253
- Wang, R.E., Wang, Y., Zhang, Y., Gabrelow, C., Zhang, Y., Chi, V., Fu, Q., Luo, X., Wang, D., Joseph, S., Johnson, K., Chatterjee, A.K., Wright, T.M., Nguyen-Tran, V.T.B., Teijaro, J., Theofilopoulos, A.N., Schultz, P.G. and Wang, F. Rational Design of a Kv1.3 Channel-Blocking Antibody as a Selective Immunosuppressant. Proc. Natl. Acad. Sci. U.S.A., 2016, 113, 11501-11506. PMC5068325
- Zhang, Y., Zou, H., Wang, Y., Caballero, D., Gonzalez, J., Chao, E., Welzel, G., Shen, W., Wang, D., Schultz, P.G. and Wang, F. Rational Design of a Humanized Glucagon-Like Peptide-1 Receptor Agonist Antibody. Angew. Chem. Int. Ed. Engl., 2015, 54, 2126-30.
PMID25556336 - Liu, T., Zhang, Y. (co-first author), Liu, Y., Wang, Y., Jia, H., Kang, M., Luo, X., Caballero, D., Gonzalez, J., Wang, D., Woods, A., Schultz, P.G. and Wang, F. Functional Human Antibody CDR Fusions as Long-Acting Therapeutic Endocrine Agonists. Proc. Natl. Acad. Sci. U.S.A., 2015,112,1356-61. PMC4321239
- Zhang, Y. (co-first author), Liu, Y., Wang, Y., Schultz, P.G. and Wang, F. Rational Design of Humanized Dual-Agonist Antibodies. J. Am. Chem. Soc., 2015, 137, 38-41.
PMID25494484 - Lu, H., Zhou, Q., Deshmukh, V., Phull, H., Ma, J., Tardif, V., Naik, R.R., Bouvard, C., Zhang, Y., Choi, S., Lawson, B.R., Zhu, S., Kim, C.H. and Schultz, P.G. Targeting Human C-Type Lectin-like Molecule-1 (CLL1) with a Bispecific Antibody for Immunotherapy of Acute Myeloid Leukemia. Angew. Chem. Int. Ed. Engl., 2014, 53, 9841–9845. PMC4280064
- Zhang, Y., Goswami, D., Wang, D., Wang, T.S.A., Sen, S., Magliery, T.J., Griffin, P.R., Wang, F. and Schultz, P.G. An Antibody with a Variable Region Coiled-Coil “Knob” Domain. Angew. Chem. Int. Ed. Engl., 2014, 53, 132-135. PMC3926434
- Zhang, Y., Evans, G.B., Clinch, K., Crump, D.R., Harris, L.D., Fröhlich, R.F.G., Tyler, P.C., Hazleton, K.Z., Cassera, M.B. and Schramm, V.L. Transition State Analogues of Plasmodium falciparum and Human Orotate Phosphoribosyltransferases. J. Biol. Chem., 2013, 288, 34746-54. PMC3843086
- Zhang, Y., Wang, D., Welzel, G., Wang, Y., Schultz, P.G. and Wang, F. An Antibody CDR3-Erythropoietin Fusion Protein. ACS Chem. Biol., 2013, 8, 2117-2121. PMC3800483
- Zhang, Y., Wang, D., de Lichtervelde, L., Sun, S.B., Smider, V.V., Schultz, P.G. and Wang, F. Functional Antibody CDR3 Fusion Proteins with Enhanced Pharmacological Properties. Angew. Chem. Int. Ed. Engl., 2013, 52, 8295-8298. PMC3783209
- Wang, F., Sambandan, D., Wang, J., Halder, R., Batt, S., Weinrick, B.C., Ahmad, I., Yang, P, Zhang, Y., Kim, J., Hassani, M., Huszar, S., Mikusova, K., Chatterjee, A., Besra, G., Futterer, K., Jacobs, W.R. Jr. and Schultz, P.G. Identification of a Small Molecule with Activity against Drug-resistant and Persistent Tuberculosis. Proc. Natl. Acad. Sci. U.S.A., 2013, 110, E2510-7. PMC3703973
- Wang, F., Ekiert, D.C., Ahmad, I., Li, W., Zhang, Y., Bazirgan, O., Torkamani, A., Raudsepp, T., Mwangi, W., Criscitiello, M.F., Wilson, I.A., Schultz, P.G. and Smider. V.V. Reshaping Antibody Diversity. Cell, 2013, 153, 1379-93. PMC4007204
- Cassera, M.B., Zhang, Y. (co-first author), Hazleton, K.Z. and Schramm, V.L. Purine and Pyrimidine Pathways as Targets in Plasmodium falciparum. Curr. Top. Med. Chem., 2011, 11, 2103-2115. PMC3319363
- Zhang, Y. and Schramm, V.L. Ground-State Destabilization in Orotate Phosphoribosyltransferases by Binding Isotope Effects. Biochemistry, 2011, 50, 4813-4818. PMC3101270
- Vetting, M.W., Hegde, S.S., Zhang, Y. and Blanchard, J.S. Pentapeptide Repeat Proteins that Act as Topisomerase Poison Resistance Factors Have a Common Dimer Interface. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 2011, 67, 296-302. PMC3053150
- Zhang, Y., Deng, H. and Schramm, V.L. Leaving Group Activation and Pyrophosphate Ionic State at the Catalytic Site of Plasmodium falciparum Orotate Phosphoribosyltransferase. J. Am. Chem. Soc., 2010, 132, 17023-17031. PMC3012390
- Zhang, Y. and Schramm, V.L. Pyrophosphate Interactions at the Transition States of Plasmodium falciparum and Human Orotate Phosphoribosyltransferases. J. Am. Chem. Soc., 2010, 132, 8787-8794. PMC2892240
- Abdo, M., Zhang, Y., Schramm, V.L. and Knapp, S. Electrophilic Aromatic Selenylation: New OPRT Inhibitors. Org. Lett., 2010, 12, 2982-2985. PMC2906230
- Zhang, Y., Luo, M. and Schramm, V.L. Transition States of Plasmodium falciparum and Human Orotate Phosphoribosyltransferases. J. Am. Chem. Soc., 2009, 131, 4685-4694. PMC2669657
- Zhang, Y. (co-first author), Liu, S., Lajoie G. and Merrill, A.R. The Role of the Diphthamide-containing Loop within Eukaryotic Elongation Factor 2 in ADP-Ribosylation by Pseudomonas aeruginosa Exotoxin A. Biochem. J., 2008, 413, 163-174. PMID18373493