Goal: To investigate the prediction value of MR plaque imaging for stroke recurrence
To learn more, please refer to this video.
Inclusion Criteria
- Ischemic stroke or high-risk TIA (with ABCD score >= 4) that happens within 2 weeks prior to baseline recruitment.
- Age ≥30 years.
- The event has been adjudicated to be localized to a territory of intracranial circulation.
- At least one luminal stenosis in a major intracranial artery (ICA, MCA, ACA, VA, BA, and PCA), as seen on CTA, MRA or DSA, within the corresponding arterial territory.
- The presence of 2 or more vascular risk factors (hypertension, hyperlipidemia, diabetes mellitus, obesity, smoking, coronary artery disease, age >50 years for men or 60 years for women).
Exclusion Criteria
- Patients with intracranial endovascular procedure in the past 6 months at baseline recruitment
- Patients with chronic large vessel occlusion
- Conditions that prohibit MR scanning
- Estimated GFR <30 ml/min/1.73 m2
- Intracranial endovascular procedure (such as mechanical thrombectomy, stenting, angioplasty, aneurysm coiling or clipping) after the index stroke
- The MRA or CTA after the index stroke has shown >50% stenosis of the extracranial artery within the corresponding infarct area
- The diagnosis after the index stroke indicates nonatherosclerotic stenosis
- The diagnosis after the index stroke indicates a cardiac source of embolism
- Comorbid serious, advanced, or terminal illness (investigator judgment) that will limit follow up in 1 year or life expectancy is less than 1 year.
- Women who are pregnant, nursing, are implanted with intrauterine devices (IUD’s) that are not MRI compatible will be excluded from the study
Contact information: Melissa Perkins, 213-304-3886