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- Novel MAOA Inhibitor for Prostate and Brain Cancer June 7, 2021NMI for Prostate Cancer: NMI for Brain Cancer:
- MAOA Inhibitor Clinical Trial for Prostate Cancer June 7, 2021MAOA expression in human prostate cancer biopsy shows increased expression with increasing cancer malignancy and demonstrates therapeutic target opportunity. Clinical trial of MAO inhibitor demonstrated efficacy in patients with biochemical recurrent castrate-sensitive prostate cancer. link to publication: https://www.nature.com/articles/s41391-020-0211-9
- Cloning Human MAO A & B May 7, 2021https://youtu.be/vpmYTNBM3TE Dr. Jean Chen Shih, University Professor and Boyd & Elsie Welin Professor of Pharmacology and Pharmaceutical Sciences at the USC School of Pharmacy Cloning Human MAO A and MAO B • Beyond expectations • What is the molecular basis? • The summary session • They must be sequenced! • Dr. Shih wants to solve…
- Defining MAO May 6, 2021https://youtu.be/HsDpftLtMHU Where is MAO found in the human body? Where is MAO found and how are its proteins created? Cells and chromosomes DNA Genes and nucleotides Base pairs and base sequences Transcription RNA How transcribing happens Translation Amino acids tRNA and the codon The polypeptide chain Embedding in the mitochondria
- Discovering the gene structure May 7, 2021https://youtu.be/ZFCTFsdqldw What’s next? • Not at the top of the mountain yet • Different ways to go • Decisions and limitations • Two directions: structure/function and gene structure • The lottery! It matches! • An important finding
- What are enzymes, how are they made? May 7, 2021What are enzymes? https://youtu.be/lNk0U64IFBE • Enzymes• Catalysts• The function of enzymes• How do enzymes do this?• Why is this important?• A MAO A example• Amino acids and catalytic function How do genes make proteins? https://youtu.be/Y0506kiR_Eg • Transcription• Translation• Amino Acids What are introns and exons? https://youtu.be/YtKoTOCJGt4 • Intron/exon borders• Editing out for mRNA• Making proteins…
- What are the functions of MAO A and B? May 7, 2021What are chemical messengers or neurotransmitters? https://youtu.be/QDv1jX_3Ubc Chemical Messengers • Neurotransmitter • Serotonin • Serotonin receptors A neurotransmitter is a brain chemical that relays messages between brain cells and affects emotions, behavior, thoughts and regulates moods. Serotonin, norepinephrine and dopamine are just a few of the neurotransmitters present in the body. Serotonin exerts its function…
- Working with knockout mice May 7, 2021https://youtu.be/FmWLPivV2cQ • Why knockout mice are important• No progress• A phone call• Aggressive French mice• Getting the mice to Los Angeles• Testing the mice: They’re MAO A knockout mice• A Gift from heaven Why experiment with mice? https://youtu.be/j2GQo1H08r4 One of the best ways of determining the different functions of MAO A and MAO B is…
- MAO A deficiency and aggression in humans June 28, 2021Shih on the Brunner study https://youtu.be/_3W6sIjbQ3k Dr. Jean Chen Shih, University Professor and Professor of Pharmacology and Pharmaceutical Sciences at the USC School of Pharmacy Dr. Shih on Dr. Brunner’s study• The significance of Dr. Brunner’s work• The biological component of behavior The family's report https://youtu.be/kO6yS_VXtn0 “A curious case”• The grand uncle’s study: could it…
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