Novel MAOA Inhibitor for Prostate and Brain Cancer
NMI for Prostate Cancer: NMI for Brain Cancer: Continue reading Novel MAOA Inhibitor for Prostate and Brain Cancer
MAOA Inhibitor Clinical Trial for Prostate Cancer
MAOA expression in human prostate cancer biopsy shows increased expression with increasing cancer malignancy and demonstrates therapeutic target opportunity. Clinical trial of MAO inhibitor demonstrated efficacy in patients with biochemical recurrent castrate-sensitive prostate cancer. link to publication: https://www.nature.com/articles/s41391-020-0211-9 Continue reading MAOA Inhibitor Clinical Trial for Prostate Cancer
MAOA and Prostate Cancer
MAOA gene knockdown in prostate cancer mouse model: Continue reading MAOA and Prostate Cancer
Cloning Human MAO A & B
Dr. Jean Chen Shih, University Professor and Boyd & Elsie Welin Professor of Pharmacology and Pharmaceutical Sciences at the USC School of Pharmacy Cloning Human MAO A and MAO B • Beyond expectations • What is the molecular basis? • The summary session • They must be sequenced! • Dr. Shih wants to solve the … Continue reading Cloning Human MAO A & B
Defining MAO
Where is MAO found in the human body? Where is MAO found and how are its proteins created? Cells and chromosomes DNA Genes and nucleotides Base pairs and base sequences Transcription RNA How transcribing happens Translation Amino acids tRNA and the codon The polypeptide chain Embedding in the mitochondria Continue reading Defining MAO
Discovering the gene structure
What’s next? • Not at the top of the mountain yet • Different ways to go • Decisions and limitations • Two directions: structure/function and gene structure • The lottery! It matches! • An important finding Continue reading Discovering the gene structure
What are enzymes, how are they made?
What are enzymes? • Enzymes• Catalysts• The function of enzymes• How do enzymes do this?• Why is this important?• A MAO A example• Amino acids and catalytic function How do genes make proteins? • Transcription• Translation• Amino Acids What are introns and exons? • Intron/exon borders• Editing out for mRNA• Making proteins In addition, consider … Continue reading What are enzymes, how are they made?
What are the functions of MAO A and B?
What are chemical messengers or neurotransmitters? Chemical Messengers • Neurotransmitter • Serotonin • Serotonin receptors A neurotransmitter is a brain chemical that relays messages between brain cells and affects emotions, behavior, thoughts and regulates moods. Serotonin, norepinephrine and dopamine are just a few of the neurotransmitters present in the body. Serotonin exerts its function by … Continue reading What are the functions of MAO A and B?
Working with knockout mice
• Why knockout mice are important• No progress• A phone call• Aggressive French mice• Getting the mice to Los Angeles• Testing the mice: They’re MAO A knockout mice• A Gift from heaven Why experiment with mice? One of the best ways of determining the different functions of MAO A and MAO B is using experiments … Continue reading Working with knockout mice
MAO A deficiency and aggression in humans
Shih on the Brunner study Dr. Jean Chen Shih, University Professor and Professor of Pharmacology and Pharmaceutical Sciences at the USC School of Pharmacy Dr. Shih on Dr. Brunner’s study• The significance of Dr. Brunner’s work• The biological component of behavior The family’s report “A curious case”• The grand uncle’s study: could it be inherited?• … Continue reading MAO A deficiency and aggression in humans