Dr. Jean Chen Shih, University Professor and Boyd & Elsie Welin Professor of Pharmacology and Pharmaceutical Sciences at the USC School of Pharmacy Cloning Human MAO A and MAO B • Beyond expectations • What is the molecular basis? • The summary session • They must be sequenced! • Dr. Shih wants to solve the … Continue reading Cloning Human MAO A & B
Where is MAO found in the human body? Where is MAO found and how are its proteins created? Cells and chromosomes DNA Genes and nucleotides Base pairs and base sequences Transcription RNA How transcribing happens Translation Amino acids tRNA and the codon The polypeptide chain Embedding in the mitochondria Continue reading Defining MAO
What’s next? • Not at the top of the mountain yet • Different ways to go • Decisions and limitations • Two directions: structure/function and gene structure • The lottery! It matches! • An important finding Continue reading Discovering the gene structure
What are enzymes? • Enzymes• Catalysts• The function of enzymes• How do enzymes do this?• Why is this important?• A MAO A example• Amino acids and catalytic function How do genes make proteins? • Transcription• Translation• Amino Acids What are introns and exons? • Intron/exon borders• Editing out for mRNA• Making proteins In addition, consider … Continue reading What are enzymes, how are they made?
What are chemical messengers or neurotransmitters? Chemical Messengers • Neurotransmitter • Serotonin • Serotonin receptors A neurotransmitter is a brain chemical that relays messages between brain cells and affects emotions, behavior, thoughts and regulates moods. Serotonin, norepinephrine and dopamine are just a few of the neurotransmitters present in the body. Serotonin exerts its function by … Continue reading What are the functions of MAO A and B?