Publications

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  • Falcone, M, Salhia, B, Hughes Halbert, C, Roussos Torres, ET, Stewart, D, Stern, MC et al.. Impact of Structural Racism and Social Determinants of Health on Disparities in Breast Cancer Mortality. Cancer Res. 2024;84 (23):3924-3935. doi: 10.1158/0008-5472.CAN-24-1359. PubMed PMID:39356624 PubMed Central PMC11611670.
  • Shatsky, RA, Trivedi, MS, Yau, C, Nanda, R, Rugo, HS, Davidian, M et al.. Datopotamab-deruxtecan plus durvalumab in early-stage breast cancer: the sequential multiple assignment randomized I-SPY2.2 phase 2 trial. Nat Med. 2024;30 (12):3737-3747. doi: 10.1038/s41591-024-03267-1. PubMed PMID:39277672 .
  • Khoury, K, Meisel, JL, Yau, C, Rugo, HS, Nanda, R, Davidian, M et al.. Datopotamab-deruxtecan in early-stage breast cancer: the sequential multiple assignment randomized I-SPY2.2 phase 2 trial. Nat Med. 2024;30 (12):3728-3736. doi: 10.1038/s41591-024-03266-2. PubMed PMID:39277671 .
  • Barbetta, A, Bangerth, S, Lee, JTC, Rocque, B, Roussos Torres, ET, Kohli, R et al.. IMmuneCite: an integrated workflow for analysis of immune enriched spatial proteomic data. Res Sq. 2024; :. doi: 10.21203/rs.3.rs-4571625/v2. PubMed PMID:39041033 PubMed Central PMC11261960.
  • Iriondo, O, Mecenas, D, Li, Y, Chin, CR, Thomas, A, Moriarty, A et al.. Hypoxic Memory Mediates Prolonged Tumor-Intrinsic Type I Interferon Suppression to Promote Breast Cancer Progression. Cancer Res. 2024;84 (19):3141-3157. doi: 10.1158/0008-5472.CAN-23-2028. PubMed PMID:38990731 PubMed Central PMC11444891.
  • Lake, KE, Colonnetta, MM, Smith, CA, Saunders, K, Martinez-Algarin, K, Mohta, S et al.. Digital droplet PCR analysis of organoids generated from mouse mammary tumors demonstrates proof-of-concept capture of tumor heterogeneity. Front Cell Dev Biol. 2024;12 :1358583. doi: 10.3389/fcell.2024.1358583. PubMed PMID:38827528 PubMed Central PMC11140600.
  • Baugh, AG, Gonzalez, E, Narumi, VH, Kreger, J, Liu, Y, Rafie, C et al.. A new Neu-a syngeneic model of spontaneously metastatic HER2-positive breast cancer. Clin Exp Metastasis. 2024;41 (5):733-746. doi: 10.1007/s10585-024-10289-z. PubMed PMID:38717519 PubMed Central PMC11499368.
  • Hsu, R, Al-Zubeidy, B, Flores, D, Nazarian, A, Baugh, A, Gonzalez, E et al.. Evaluation of markers of immunity in different metastatic immune microenvironments suggests more suppression within breast to liver metastases in breast cancer. Breast Cancer Res Treat. 2024;206 (2):245-259. doi: 10.1007/s10549-024-07295-w. PubMed PMID:38643348 PubMed Central PMC11182800.
  • Xu, L, Saunders, K, Huang, SP, Knutsdottir, H, Martinez-Algarin, K, Terrazas, I et al.. A comprehensive single-cell breast tumor atlas defines epithelial and immune heterogeneity and interactions predicting anti-PD-1 therapy response. Cell Rep Med. 2024;5 (5):101511. doi: 10.1016/j.xcrm.2024.101511. PubMed PMID:38614094 PubMed Central PMC11148512.
  • Roussos Torres, ET, Ho, WJ, Danilova, L, Tandurella, JA, Leatherman, J, Rafie, C et al.. Entinostat, nivolumab and ipilimumab for women with advanced HER2-negative breast cancer: a phase Ib trial. Nat Cancer. 2024;5 (6):866-879. doi: 10.1038/s43018-024-00729-w. PubMed PMID:38355777 PubMed Central PMC11552660.
  • Baugh, AG, Gonzalez, E, Narumi, VH, Kreger, J, Liu, Y, Rafie, C et al.. Mimicking the breast metastatic microenvironment: characterization of a novel syngeneic model of HER2+ breast cancer. bioRxiv. 2024; :. doi: 10.1101/2024.01.25.577282. PubMed PMID:38352476 PubMed Central PMC10862766.
  • Kreger, J, Roussos Torres, ET, MacLean, AL. Myeloid-Derived Suppressor-Cell Dynamics Control Outcomes in the Metastatic Niche. Cancer Immunol Res. 2023;11 (5):614-628. doi: 10.1158/2326-6066.CIR-22-0617. PubMed PMID:36848523 PubMed Central PMC10155038.
  • Lake, KE, Colonetta, MM, Smith, CA, Martinez-Algarin, K, Saunders, K, Mohta, S et al.. Organoid generation from mouse mammary tumors captures the genetic heterogeneity of clinically relevant copy number alterations. bioRxiv. 2023; :. doi: 10.1101/2023.01.29.526141. PubMed PMID:36778256 PubMed Central PMC9915482.
  • Jayachandran, P, Battaglin, F, Strelez, C, Lenz, A, Algaze, S, Soni, S et al.. Breast cancer and neurotransmitters: emerging insights on mechanisms and therapeutic directions. Oncogene. 2023;42 (9):627-637. doi: 10.1038/s41388-022-02584-4. PubMed PMID:36650218 PubMed Central PMC9957733.
  • Cornelius, SL, Colonnetta, MM, Lake, KE, Smith, CA, Zhang, YA, Roussos-Torres, ET et al.. Generating and Imaging Mouse and Human Epithelial Organoids from Normal and Tumor Mammary Tissue Without Passaging. J Vis Exp. 2022; (189):. doi: 10.3791/64626. PubMed PMID:36440890 PubMed Central PMC10149050.
  • Battaglin, F, Jayachandran, P, Strelez, C, Lenz, A, Algaze, S, Soni, S et al.. Neurotransmitter signaling: a new frontier in colorectal cancer biology and treatment. Oncogene. 2022;41 (43):4769-4778. doi: 10.1038/s41388-022-02479-4. PubMed PMID:36182970 PubMed Central PMC10591256.
  • Roussos Torres, ET. Revival and Recharacterization of a Preclinical Model of Hormone-Dependent Breast Cancer to Study Immunotherapy. Cancer Immunol Res. 2022;10 (6):672-673. doi: 10.1158/2326-6066.CIR-22-0315. PubMed PMID:35544128 .
  • Sidiropoulos, DN, Rafie, CI, Jang, JK, Castanon, S, Baugh, AG, Gonzalez, E et al.. Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2+ Breast Tumor Microenvironment. Cancer Immunol Res. 2022;10 (5):656-669. doi: 10.1158/2326-6066.CIR-21-0170. PubMed PMID:35201318 PubMed Central PMC9064912.
  • Erbe, R, Wang, Z, Wu, S, Xiu, J, Zaidi, N, La, J et al.. Evaluating the impact of age on immune checkpoint therapy biomarkers. Cell Rep. 2021;37 (7):110033. doi: 10.1016/j.celrep.2021.110033. PubMed PMID:34788629 .
  • Erbe, R, Wang, Z, Wu, S, Xiu, J, Zaidi, N, La, J et al.. Evaluating the impact of age on immune checkpoint therapy biomarkers. Cell Rep. 2021;36 (8):109599. doi: 10.1016/j.celrep.2021.109599. PubMed PMID:34433020 PubMed Central PMC8757482.
  • Goode, EF, Roussos Torres, ET, Irshad, S. Lymph Node Immune Profiles as Predictive Biomarkers for Immune Checkpoint Inhibitor Response. Front Mol Biosci. 2021;8 :674558. doi: 10.3389/fmolb.2021.674558. PubMed PMID:34141724 PubMed Central PMC8205515.
  • Roussos Torres, ET, Rafie, C, Wang, C, Lim, D, Brufsky, A, LoRusso, P et al.. Phase I Study of Entinostat and Nivolumab with or without Ipilimumab in Advanced Solid Tumors (ETCTN-9844). Clin Cancer Res. 2021;27 (21):5828-5837. doi: 10.1158/1078-0432.CCR-20-5017. PubMed PMID:34135021 PubMed Central PMC8563383.
  • Battaglin, F, Chan, P, Pan, Y, Soni, S, Qu, M, Spiller, ER et al.. Clocking cancer: the circadian clock as a target in cancer therapy. Oncogene. 2021;40 (18):3187-3200. doi: 10.1038/s41388-021-01778-6. PubMed PMID:33846572 PubMed Central PMC8549632.
  • Roussos Torres, ET, Epstein, AL. Adopting an alternative structure for clinical trials in immunotherapy. Expert Rev Anticancer Ther. 2021;21 (4):373-375. doi: 10.1080/14737140.2021.1875822. PubMed PMID:33435760 .
  • Mirando, AC, Patil, A, Rafie, CI, Christmas, BJ, Pandey, NB, Stearns, V et al.. Regulation of the tumor immune microenvironment and vascular normalization in TNBC murine models by a novel peptide. Oncoimmunology. 2020;9 (1):1760685. doi: 10.1080/2162402X.2020.1760685. PubMed PMID:32923118 PubMed Central PMC7458646.
  • Sheng, JY, Santa-Maria, CA, Mangini, N, Norman, H, Couzi, R, Nunes, R et al.. Management of Breast Cancer During the COVID-19 Pandemic: A Stage- and Subtype-Specific Approach. JCO Oncol Pract. 2020;16 (10):665-674. doi: 10.1200/OP.20.00364. PubMed PMID:32603252 PubMed Central PMC7564133.
  • Sharma, P, Connolly, RM, Roussos Torres, ET, Thompson, A. Best Foot Forward: Neoadjuvant Systemic Therapy as Standard of Care in Triple-Negative and HER2-Positive Breast Cancer. Am Soc Clin Oncol Educ Book. 2020;40 :1-16. doi: 10.1200/EDBK_281381. PubMed PMID:32315235 .
  • Wang, H, Sové, RJ, Jafarnejad, M, Rahmeh, S, Jaffee, EM, Stearns, V et al.. Conducting a Virtual Clinical Trial in HER2-Negative Breast Cancer Using a Quantitative Systems Pharmacology Model With an Epigenetic Modulator and Immune Checkpoint Inhibitors. Front Bioeng Biotechnol. 2020;8 :141. doi: 10.3389/fbioe.2020.00141. PubMed PMID:32158754 PubMed Central PMC7051945.
  • Davis-Marcisak, EF, Sherman, TD, Orugunta, P, Stein-O'Brien, GL, Puram, SV, Roussos Torres, ET et al.. Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data. Cancer Res. 2019;79 (19):5102-5112. doi: 10.1158/0008-5472.CAN-18-3882. PubMed PMID:31337651 PubMed Central PMC6844448.
  • Ma, HS, Poudel, B, Torres, ER, Sidhom, JW, Robinson, TM, Christmas, B et al.. A CD40 Agonist and PD-1 Antagonist Antibody Reprogram the Microenvironment of Nonimmunogenic Tumors to Allow T-cell-Mediated Anticancer Activity. Cancer Immunol Res. 2019;7 (3):428-442. doi: 10.1158/2326-6066.CIR-18-0061. PubMed PMID:30642833 PubMed Central PMC6397686.
  • Christmas, BJ, Rafie, CI, Hopkins, AC, Scott, BA, Ma, HS, Cruz, KA et al.. Entinostat Converts Immune-Resistant Breast and Pancreatic Cancers into Checkpoint-Responsive Tumors by Reprogramming Tumor-Infiltrating MDSCs. Cancer Immunol Res. 2018;6 (12):1561-1577. doi: 10.1158/2326-6066.CIR-18-0070. PubMed PMID:30341213 PubMed Central PMC6279584.
  • Gligorijevic, B, Wyckoff, J, Yamaguchi, H, Wang, Y, Roussos, ET, Condeelis, J et al.. N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors. J Cell Sci. 2012;125 (Pt 3):724-34. doi: 10.1242/jcs.092726. PubMed PMID:22389406 PubMed Central PMC3367832.
  • Entenberg, D, Wyckoff, J, Gligorijevic, B, Roussos, ET, Verkhusha, VV, Pollard, JW et al.. Setup and use of a two-laser multiphoton microscope for multichannel intravital fluorescence imaging. Nat Protoc. 2011;6 (10):1500-20. doi: 10.1038/nprot.2011.376. PubMed PMID:21959234 PubMed Central PMC4028841.
  • Roussos, ET, Condeelis, JS, Patsialou, A. Chemotaxis in cancer. Nat Rev Cancer. 2011;11 (8):573-87. doi: 10.1038/nrc3078. PubMed PMID:21779009 PubMed Central PMC4030706.
  • Roussos, ET, Balsamo, M, Alford, SK, Wyckoff, JB, Gligorijevic, B, Wang, Y et al.. Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. J Cell Sci. 2011;124 (Pt 13):2120-31. doi: 10.1242/jcs.086231. PubMed PMID:21670198 PubMed Central PMC3113666.
  • Roussos, ET, Goswami, S, Balsamo, M, Wang, Y, Stobezki, R, Adler, E et al.. Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM. Clin Exp Metastasis. 2011;28 (6):515-27. doi: 10.1007/s10585-011-9388-6. PubMed PMID:21484349 PubMed Central PMC3459587.
  • Roussos, ET, Wang, Y, Wyckoff, JB, Sellers, RS, Wang, W, Li, J et al.. Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors. Breast Cancer Res. 2010;12 (6):R101. doi: 10.1186/bcr2784. PubMed PMID:21108830 PubMed Central PMC3046446.
  • Roussos, ET, Keckesova, Z, Haley, JD, Epstein, DM, Weinberg, RA, Condeelis, JS et al.. AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment. Cancer Res. 2010;70 (19):7360-4. doi: 10.1158/0008-5472.CAN-10-1208. PubMed PMID:20823151 .
  • Pang, H, Flinn, R, Patsialou, A, Wyckoff, J, Roussos, ET, Wu, H et al.. Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase. Cancer Res. 2009;69 (23):8868-76. doi: 10.1158/0008-5472.CAN-09-1968. PubMed PMID:19903845 PubMed Central PMC2793177.
  • Philippar, U, Roussos, ET, Oser, M, Yamaguchi, H, Kim, HD, Giampieri, S et al.. A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell. 2008;15 (6):813-28. doi: 10.1016/j.devcel.2008.09.003. PubMed PMID:19081071 PubMed Central PMC2637261.
  • Mao, HZ, Roussos, ET, Péterfy, M. Genetic analysis of the diabetes-prone C57BLKS/J mouse strain reveals genetic contribution from multiple strains. Biochim Biophys Acta. 2006;1762 (4):440-6. doi: 10.1016/j.bbadis.2006.01.002. PubMed PMID:16481151 .
  • Ma, MH, Yang, HH, Parker, K, Manyak, S, Friedman, JM, Altamirano, C et al.. The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents. Clin Cancer Res. 2003;9 (3):1136-44. . PubMed PMID:12631619 .
  • Parker, KM, Ma, MH, Manyak, S, Altamirano, CV, Tang, YM, Frantzen, M et al.. Identification of polymorphisms of the IkappaBalpha gene associated with an increased risk of multiple myeloma. Cancer Genet Cytogenet. 2002;137 (1):43-8. doi: 10.1016/s0165-4608(02)00541-1. PubMed PMID:12377412 .

Ma, HS, Poudel, B, Torres, ER, Sidhom, JW, Robinson, TM, Christmas, B et al.. A CD40 Agonist and PD-1 Antagonist Antibody Reprogram the Microenvironment of Nonimmunogenic Tumors to Allow T-cell-Mediated Anticancer Activity. Cancer Immunol Res. 2019;7 (3):428-442. doi: 10.1158/2326-6066.CIR-18-0061. PubMed PMID:30642833 PubMed Central PMC6397686.

Gligorijevic, B, Wyckoff, J, Yamaguchi, H, Wang, Y, Roussos, ET, Condeelis, J et al.. N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors. J Cell Sci. 2012;125 (Pt 3):724-34. doi: 10.1242/jcs.092726. PubMed PMID:22389406 PubMed Central PMC3367832.

Entenberg, D, Wyckoff, J, Gligorijevic, B, Roussos, ET, Verkhusha, VV, Pollard, JW et al.. Setup and use of a two-laser multiphoton microscope for multichannel intravital fluorescence imaging. Nat Protoc. 2011;6 (10):1500-20. doi: 10.1038/nprot.2011.376. PubMed PMID:21959234 PubMed Central PMC4028841.

Roussos, ET, Condeelis, JS, Patsialou, A. Chemotaxis in cancer. Nat Rev Cancer. 2011;11 (8):573-87. doi: 10.1038/nrc3078. PubMed PMID:21779009 PubMed Central PMC4030706.

Roussos, ET, Balsamo, M, Alford, SK, Wyckoff, JB, Gligorijevic, B, Wang, Y et al.. Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. J Cell Sci. 2011;124 (Pt 13):2120-31. doi: 10.1242/jcs.086231. PubMed PMID:21670198 PubMed Central PMC3113666.

Roussos, ET, Goswami, S, Balsamo, M, Wang, Y, Stobezki, R, Adler, E et al.. Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM. Clin Exp Metastasis. 2011;28 (6):515-27. doi: 10.1007/s10585-011-9388-6. PubMed PMID:21484349 PubMed Central PMC3459587.

Roussos, ET, Wang, Y, Wyckoff, JB, Sellers, RS, Wang, W, Li, J et al.. Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors. Breast Cancer Res. 2010;12 (6):R101. doi: 10.1186/bcr2784. PubMed PMID:21108830 PubMed Central PMC3046446.

Roussos, ET, Keckesova, Z, Haley, JD, Epstein, DM, Weinberg, RA, Condeelis, JS et al.. AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment. Cancer Res. 2010;70 (19):7360-4. doi: 10.1158/0008-5472.CAN-10-1208. PubMed PMID:20823151 .

Pang, H, Flinn, R, Patsialou, A, Wyckoff, J, Roussos, ET, Wu, H et al.. Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase. Cancer Res. 2009;69 (23):8868-76. doi: 10.1158/0008-5472.CAN-09-1968. PubMed PMID:19903845 PubMed Central PMC2793177.

Philippar, U, Roussos, ET, Oser, M, Yamaguchi, H, Kim, HD, Giampieri, S et al.. A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell. 2008;15 (6):813-28. doi: 10.1016/j.devcel.2008.09.003. PubMed PMID:19081071 PubMed Central PMC2637261.

Mao, HZ, Roussos, ET, Péterfy, M. Genetic analysis of the diabetes-prone C57BLKS/J mouse strain reveals genetic contribution from multiple strains. Biochim Biophys Acta. 2006;1762 (4):440-6. doi: 10.1016/j.bbadis.2006.01.002. PubMed PMID:16481151 .

Ma, MH, Yang, HH, Parker, K, Manyak, S, Friedman, JM, Altamirano, C et al.. The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents. Clin Cancer Res. 2003;9 (3):1136-44. . PubMed PMID:12631619 .

Parker, KM, Ma, MH, Manyak, S, Altamirano, CV, Tang, YM, Frantzen, M et al.. Identification of polymorphisms of the IkappaBalpha gene associated with an increased risk of multiple myeloma. Cancer Genet Cytogenet. 2002;137 (1):43-8. doi: 10.1016/s0165-4608(02)00541-1. PubMed PMID:12377412 .

Roussos Torres ET, Connolly RM. Optimizing HER2-Directed Therapy in Early-Stage Breast Cancer. Current breast cancer reports. 2018 November; 10(4):262. doi: 10.1007/s12609-018-0296-5.

Sidiropoulos DN, Rafie C, Christmas BJ, Davis-Marcisak EF, Sharma G, Bigelow E, Gupta A, Yegnasubramanian S, Stearns V, Connolly RM, Gaykalova DA, Kagohara LT, Jaffee EM, Fertig EJ, Roussos Torres ET. Phenotypic shifts of tumor associated macrophages and STAT3 mediated suppression of myeloid derived suppressor cells drive sensitization of HER2 tumor immunity. Bioxriv. 2021 January; :2021.01.29.428708. doi: 10.1101/2021.01.29.428708.

University of Southern California