Cellular phenotyping across thick tissues in vivo and in situ
Systemic targeting of cells across the PNS and CNS with engineered AAV capsids
Combining PACT clearing, systemic targeting, and HCR
Neurophysiological Profiling and Ultrasound Neuromodulation
Low Intensity Focused Ultrasound
&
Whole Cell Patch Clamping
Noninvasively modulating neural signaling in CNS and PNS will advance our understanding of neural circuits and their effect on homeostasis and diseases. Herein, we have developed a focused ultrasound probe attached to an acoustic waveguide to stimulate neurons/nerves during whole cell patch clamping procedure. This technique can elucidate the mechanisms that ultrasound modulates neuronal signaling and guide the design of non-invasive devices for clinical applications.
