Uncovering the genetic and epigenetic sequence variation that underlies the predisposition, initiation, and progression of cancer is critical within the field of cancer research. As such, the mission of the Molecular Genomics Core (MGC) is to provide services for industry-standard and state-of-the-art molecular and genomic assays in support of USC Norris investigators working across the continuum of basic, translational, clinical and population sciences. The MGC scientific leadership works with USC Norris investigators on the planning, design, conduct, analysis, and reporting for molecular cancer research studies. Thus, the MGC serves as a key foundational element enabling infrastructure and providing molecular platforms and assays for all five USC Norris Research Programs.